Digestive Diseases and Sciences

, Volume 53, Issue 9, pp 2387–2393

Yield of 24-Hour Esophageal pH and Bilitec Monitoring in Patients with Persisting Symptoms on PPI Therapy

  • George Karamanolis
  • Tim Vanuytsel
  • Daniel Sifrim
  • Raf Bisschops
  • Joris Arts
  • Philip Caenepeel
  • Dominiek Dewulf
  • Jan Tack
Original Paper

DOI: 10.1007/s10620-007-0186-6

Cite this article as:
Karamanolis, G., Vanuytsel, T., Sifrim, D. et al. Dig Dis Sci (2008) 53: 2387. doi:10.1007/s10620-007-0186-6

Abstract

Current management algorithms propose pH monitoring under proton pump inhibitors (PPIs) in suspected gastroesophageal reflux disease (GERD) with insufficient treatment response, but recent observations challenge this approach because of its low yield. Aim To perform an audit of the outcomes of pH monitoring under PPI therapy in our unit, and to study the yield of additional nonacid reflux monitoring. Methods All pH monitoring studies under antireflux therapy since 1997, with or without simultaneous Bilitec® monitoring, were analyzed. Results From 1997 to 2003, 347 patients (157 men, mean age 49.4 ± 0.8 years) underwent pH studies on PPI therapy (28% half-, 67% full-, and 5% double-dose PPI) for persisting typical (53%) or atypical (75%) symptoms. In 184 patients, simultaneous Bilitec® monitoring was performed. Esophageal pH monitoring on PPI was pathological in 105 (30%) patients. Pathological pH monitoring on PPI was associated with typical reflux symptoms (64 versus 52%, P = 0.03), and a higher prevalence of persisting esophagitis (54 versus 36%, P < 0.005) and of hiatal hernia (58 versus 27%, P < 0.005). Bilitec monitoring on PPI therapy was pathological in 114 (62%) patients, of which 74 (40%) had normal pH monitoring. Adding Bilitec® increased the rate of abnormal results over pH monitoring alone, from 38% to 69% on half-dose, from 27% to 69% on full-dose, and from 0% to 38% on double-dose PPI. Conclusions The rate of abnormal pH monitoring in symptomatic GERD patients while on PPI therapy is relatively low, especially in those on double-dose PPI. Combined pH and Bilitec® monitoring significantly increased the rate of ongoing pathological reflux compared to pH alone in refractory to PPI therapy GERD patients.

Keywords

Gastro-esophageal reflux disease pH monitoring Bilitec monitoring Proton pump inhibitor therapy Bile reflux 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • George Karamanolis
    • 1
  • Tim Vanuytsel
    • 1
  • Daniel Sifrim
    • 1
  • Raf Bisschops
    • 1
  • Joris Arts
    • 1
  • Philip Caenepeel
    • 1
  • Dominiek Dewulf
    • 1
  • Jan Tack
    • 1
    • 2
  1. 1.Division of Gastroenterology, Department of PathophysiologyUniversity Hospital Gasthuisberg, University of LeuvenLeuvenBelgium
  2. 2.Division of Gastroenterology, Department of Internal MedicineUniversity Hospital GasthuisbergLeuvenBelgium

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