Digestive Diseases and Sciences

, Volume 53, Issue 7, pp 1842–1845

The Short-Term Effects of Different Doses of Dexamethasone on the Numbers of some Bacteria in the Ileum

  • Hümeyra Ünsal
  • Muharrem Balkaya
  • Cengiz Ünsal
  • Halil Bıyık
  • Gamze Başbülbül
  • Esin Poyrazoğlu
Original Paper

DOI: 10.1007/s10620-007-0089-6

Cite this article as:
Ünsal, H., Balkaya, M., Ünsal, C. et al. Dig Dis Sci (2008) 53: 1842. doi:10.1007/s10620-007-0089-6

Abstract

Glucocorticoids are known to affect intestinal biota both directly or indirectly. The aim of the study reported here was to determine the short-term effects of different doses of dexamethasone on the numbers of various ileal bacteria populations. Rats were randomly put into groups, and each group was administered a single-dose injection of dexamethasone at either 0.1, 0.5, 1, 2.5, 5, or 10 mg/kg body weight. At 48-h post-injection, the numbers of total aerobe, anaerobe, lactobacilli and coliform bacteria in the ileum were determined. The numbers of total aerobes and lactobacilli were higher in the groups receiving 5 and 10 mg/kg dexamethasone than in the control and other dose groups (P < 0.01 and P < 0.001, respectively). The number of ileal anaerobic bacteria was higher in group receiving 5 mg/kg than in the other groups (P < 0.01). There were more coliform bacteria in the group receiving 0.1 mg/kg than in the groups receiving 0.5, 1 and 10 mg/kg (P < 0.05). In light of these results, the effects of dose-dependent increases in the number of different bacterial groups affecting gut functions have still to be determined in future studies.

Keywords

DexamethasoneIntestineMicrobiotaStress

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Hümeyra Ünsal
    • 1
  • Muharrem Balkaya
    • 1
  • Cengiz Ünsal
    • 1
  • Halil Bıyık
    • 2
  • Gamze Başbülbül
    • 2
  • Esin Poyrazoğlu
    • 2
  1. 1.Department of Physiology, Faculty of Veterinary MedicineAdnan Menderes UniversityIsikli, AydinTurkey
  2. 2.Department of Biology, Faculty of Art and SciencesAdnan Menderes UniversityIsikli, AydinTurkey