Digestive Diseases and Sciences

, Volume 53, Issue 7, pp 1865–1868

Tumour Necrosis Factor Alpha in Segmental Colitis Associated with Diverticula

  • Enzo Ierardi
  • Gianmichele Meucci
  • Cesare Hassan
  • Angelo Zullo
  • Gianni Imperiali
  • Vincenzo De Francesco
  • Carmine Panella
  • Sergio Morini
  • Giorgio Minoli
Original Paper

DOI: 10.1007/s10620-007-0086-9

Cite this article as:
Ierardi, E., Meucci, G., Hassan, C. et al. Dig Dis Sci (2008) 53: 1865. doi:10.1007/s10620-007-0086-9

Abstract

The pathogenesis of segmental colitis associated with diverticula (SCAD) is unclear, but tumour necrosis factor alpha (TNF-α) has been shown to play a pivotal role in the pathogenesis of inflammatory bowel diseases. The aim of this study was to assess TNF-α levels in patients with SCAD. In a post hoc analysis of a prospective multicenter study, tissue samples from 13 patients diagnosed with SCAD were subjected to histological analyses. The severity of the inflammation was assessed by means of a histological score and histomorphometry (number of inflammatory cells/mm2). Immunohistochemical staining with an antibody against TNF-α was performed on all biopsies and the degree of staining expressed as the percentage of positive stromal cells/1000 counted (TNF-α score). Matched patients with irritable bowel syndrome (IBS) were used as controls. Over-expression of TNF-α was found in all SCAD patients (38.6 ± 10.4%), and it was associated with a high histological score (2.5 ± 0.5) and neutrophil cell count (16.3 ± 3/mm2). These values were distinctly higher than those found in the IBS controls. Our data suggest that TNF-α activity is involved in SCAD pathogenesis, similarly to what occurs in Crohn’s disease and ulcerative colitis.

Keywords

Segmental colitis associated with diverticulaTNF-α

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Enzo Ierardi
    • 1
  • Gianmichele Meucci
    • 2
  • Cesare Hassan
    • 3
  • Angelo Zullo
    • 3
  • Gianni Imperiali
    • 2
  • Vincenzo De Francesco
    • 1
  • Carmine Panella
    • 1
  • Sergio Morini
    • 3
  • Giorgio Minoli
    • 2
  1. 1.Section of Gastroenterology, Department of Medical Sciences, University of FoggiaOspedali RiunitiFoggia Italy
  2. 2.Department of Gastroenterology“Valduce” HospitalComoItaly
  3. 3.Gastroenterology and Digestive Endoscopy Unit“Nuovo Regina Margherita” HospitalRomeItaly