Digestive Diseases and Sciences

, Volume 53, Issue 6, pp 1582–1588

Usefulness of Antibodies to Deamidated Gliadin Peptides in Celiac Disease Diagnosis and Follow-up

  • Umberto Volta
  • Alessandro Granito
  • Erica Fiorini
  • Claudia Parisi
  • Maria Piscaglia
  • Georgios Pappas
  • Paolo Muratori
  • Francesco B. Bianchi
Original Paper

DOI: 10.1007/s10620-007-0058-0

Cite this article as:
Volta, U., Granito, A., Fiorini, E. et al. Dig Dis Sci (2008) 53: 1582. doi:10.1007/s10620-007-0058-0

Abstract

The prevalence of the recently described deamidated gliadin peptide antibodies was compared with that of the routinely used antigliadin, antiendomysial, and tissue transglutaminase antibodies in the sera of 128 untreated celiac patients and 134 controls. Sensitivity and specificity for celiac disease were 83.6 and 90.3% for IgA and 84.4 and 98.5% for IgG antibodies to deamidated gliadin peptides. The new test displayed higher diagnostic accuracy than antigliadin antibodies and, although less sensitive than antiendomysial and tissue transglutaminase antibodies, showed significantly higher specificity than tissue transglutaminase antibodies (P < 0.001). Persistence of peptide antibodies after gluten withdrawal was an expression of low compliance with the diet and of the lack of improvement of the intestinal mucosa. The combined use of tissue transglutaminase and deamidated gliadin peptide antibodies seems to be a very useful tool for celiac disease diagnosis. Moreover, antibodies to deamidated gliadin peptides can be helpful in disease follow-up.

Keywords

Antibodies to deamidated gliadin peptidesCeliac diseaseDiagnosisFollow-up

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Umberto Volta
    • 1
  • Alessandro Granito
    • 1
  • Erica Fiorini
    • 1
  • Claudia Parisi
    • 1
  • Maria Piscaglia
    • 1
  • Georgios Pappas
    • 1
  • Paolo Muratori
    • 1
  • Francesco B. Bianchi
    • 1
  1. 1.Department of Gastroenterology and Internal Medicine, S. Orsola-Malpighi HospitalUniversity of BolognaBolognaItaly