, Volume 53, Issue 6, pp 1735-1736
Date: 21 Mar 2008

T-cell Non-Hodgkin’s Lymphoma Presenting After Clearance of Hepatitis C: A Case Report and Review of the Literature

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Several studies have linked hepatitis C virus (HCV) with B-cell non-Hodgkin’s lymphoma (NHL) [1, 2]. Gisbert et al. performed a meta-analysis which revealed a 15% higher prevalence of HCV in NHL than in the general population [3]. Yet, there is little or no mention of whether HCV increases the lifetime risk of lymphoproliferative diseases or the association of HCV with T-cell NHL.

We describe a patient who developed T-NHL after completing treatment for chronic HCV with HCV RNA negativity at the time of diagnosis.

Case report

A 55-year-old male with history of treated hepatitis C genotype 1 virus presented with a lesion on his back, fatigue, and night sweats 4 weeks prior to presentation.

His past medical history was significant for hepatitis C, depression, and post-traumatic splenectomy. On initial presentation of hepatitis C he had abnormal liver-associated enzymes with an aspartate aminotransferase (AST) of 110 IU L−1 and alanine aminotransferase (ALT) of 209. His liver biops