Digestive Diseases and Sciences

, Volume 53, Issue 7, pp 1988–1993

Atorvastatin Does Not Improve Liver Biochemistries or Mayo Risk Score in Primary Biliary Cirrhosis

  • Carmen M. Stanca
  • Nancy Bach
  • Jorge Allina
  • Carol Bodian
  • Henry BodenheimerJr.
  • Joseph A. Odin
Original Paper

DOI: 10.1007/s10620-007-0003-2

Cite this article as:
Stanca, C.M., Bach, N., Allina, J. et al. Dig Dis Sci (2008) 53: 1988. doi:10.1007/s10620-007-0003-2

Abstract

Statin treatment reduces hypercholesterolemia and may be anti-inflammatory. Case reports noted decreased alkaline phosphatase and histological improvement following statin treatment in primary biliary cirrhosis. The objective of this study was to assess the long-term effects of statin treatment in primary biliary cirrhosis. A retrospective analysis compared clinical and biochemical data from 15 hypercholesterolemic individuals with primary biliary cirrhosis who were treated long-term with atorvastatin with an age and gender matched, primary biliary cirrhosis control group. A significant decrease in total cholesterol and low-density lipoprotein (LDL)-cholesterol (p ≤ 0.002) was observed throughout atorvastatin treatment (median time 2.5 years). LDL-cholesterol levels in the control group were not significantly changed after 2 years (p > 0.050). No significant changes were noted in alanine aminotransferase (ALT), alkaline phosphatase, total bilirubin and Mayo Risk Score in either group (p > 0.05). Long-term atorvastatin treatment reduced LDL-cholesterol in primary biliary cirrhosis, but there was no evidence of any anti-inflammatory effect.

Keywords

Hydroxymethylglutaryl-coA reductase inhibitorsLiver cirrhosisBiliaryHyperlipidemiasCholesterolImmunosuppression

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Carmen M. Stanca
    • 1
  • Nancy Bach
    • 2
  • Jorge Allina
    • 2
  • Carol Bodian
    • 3
  • Henry BodenheimerJr.
    • 4
  • Joseph A. Odin
    • 2
  1. 1.Department of MedicineThe Mount Sinai School of MedicineNew YorkUSA
  2. 2.Department of MedicineThe Mount Sinai School of MedicineNew YorkUSA
  3. 3.Department of BiomathematicsThe Mount Sinai School of MedicineNew YorkUSA
  4. 4.Department of MedicineBeth Israel Medical CenterNew YorkUSA