Digestive Diseases and Sciences

, Volume 52, Issue 9, pp 2063–2068

CRP Correlates with Clinical Score in Ulcerative Colitis but Not in Crohn’s Disease

Authors

  • Alexander D. Rodgers
    • Department of Gastroenterology and HepatologyThe Queen Elizabeth Hospital
    • Department of Gastroenterology and HepatologyThe Queen Elizabeth Hospital
Original Paper

DOI: 10.1007/s10620-006-9691-2

Cite this article as:
Rodgers, A.D. & Cummins, A.G. Dig Dis Sci (2007) 52: 2063. doi:10.1007/s10620-006-9691-2

Abstract

The aim of this study was to prospectively evaluate the correlation between clinical scoring systems and C-reactive protein (CRP) in inflammatory bowel disease. The modified Harvey-Bradshaw index was used in 40 patients (58 assessments) with Crohn’s disease, and the Lichtiger score in 29 patients (36 assessments) with ulcerative colitis. In ulcerative colitis, CRP was elevated in 14%, 42%, 64%, and 83%, respectively, of subjects with quiescent, mild, moderate, and severe disease. There was a linear correlation of log(CRP) with clinical score except for proctitis. In Crohn’s disease, CRP was elevated in 54%, 70%, 75%, and 100%, respectively, of subjects with quiescent, mild, moderate, and severe disease. We conclude that the clinical score has a good correlation with CRP in ulcerative colitis except for proctitis, whereas clinical score has a poor correlation with CRP in Crohn’s disease, particularly in those with clinically quiescent, fibrostenotic, and ileal disease.

Keywords

C-reactive proteinCrohn’s diseaseErythrocyte sedimentation rateInflammatory bowel diseaseUlcerative colitis

Copyright information

© Springer Science+Business Media, LLC 2006