, Volume 52, Issue 5, pp 1279-1284
Date: 15 Mar 2007

Haptoglobin Polymorphisms Are Associated with Crohn’s Disease, Disease Behavior, and Extraintestinal Manifestations in Hungarian Patients

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Abstract

Functional differences and association with inflammatory disorders were found relating to three major haptoglobin (Hp) phenotypes. Our aim was to investigate Hp polymorphisms in Hungarian patients with Crohn’s disease (CD). Four hundred sixty-eight CD patients and 384 healthy controls were examined. Hp phenotypes were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting of the sera. The frequency of the Hp1 allele was significantly higher in CD (0.395; OR, 1.24; 95% CI, 1.02–1.52; P=0.03) compared to controls (0.345). In CD, Hp phenotype was associated with disease behavior (OR [Hp2‐1 vs other], 2.06; 95% CI, 1.29–3.28 for inflammatory behavior). Furthermore, an increased frequency of primary sclerosing cholangitis was observed in the Hp 2-2 compared to the Hp 1-1 phenotype (6.5% vs. 0.0%; P=0.039). We conclude that the Hp polymorphism is associated with CD, inflammatory disease behavior, and primary sclerosing cholangitis in Hungarian patients. Further studies are required to evaluate the significance of Hp polymorphisms in other populations from geographically diverse regions.

Maria Papp and Peter Laszlo Lakatos contributed equally to this work and both should be considered first authors.
Further Hungarian IBD Study Group members are Peter Fuszek, Henrik Csaba Horvath, Peter Vargha, Simon Fischer, and Janos Osztovits, First Department of Medicine, Semmelweis University, Budapest; Laszlo Bene, First Department of Medicine, Erzsebet Hospital, Budapest; Ferenc Nagy and Janos Lonovics, First Department of Medicine, University of Szeged, Szeged; Levente Balint, Ferenc Huoranszky, and Istvan Dobo, Department of Gastroenterology and Surgery, St. Margit Hospital, Budapest; Zsolt Tulassay, Laszlo Herszenyi, Pal Miheller, and Annamaria Nemeth, Second Department of Medicine, Semmelweis University, Budapest; Gyorgy Szekely, First Department of Medicine, Szent Janos Hospital, Budapest; and Zsuzsanna Erdelyi, Gabor Mester, Csaba Molnar, and Tunde Pandur, First Department of Medicine, Csolnoky F. County Hospital, Veszprem.