Digestive Diseases and Sciences

, Volume 52, Issue 5, pp 1279–1284

Haptoglobin Polymorphisms Are Associated with Crohn’s Disease, Disease Behavior, and Extraintestinal Manifestations in Hungarian Patients

  • Maria Papp
  • Peter Laszlo Lakatos
  • Hungarian IBD Study Group
  • Karoly Palatka
  • Ildiko Foldi
  • Miklos Udvardy
  • Jolan Harsfalvi
  • Istvan Tornai
  • Zsuzsanna Vitalis
  • Tamas Dinya
  • Agota Kovacs
  • Tamas Molnar
  • Pal Demeter
  • Janos Papp
  • Laszlo Lakatos
  • Istvan Altorjay
ORIGINAL PAPER

DOI: 10.1007/s10620-006-9615-1

Cite this article as:
Papp, M., Lakatos, P.L., Hungarian IBD Study Group et al. Dig Dis Sci (2007) 52: 1279. doi:10.1007/s10620-006-9615-1

Abstract

Functional differences and association with inflammatory disorders were found relating to three major haptoglobin (Hp) phenotypes. Our aim was to investigate Hp polymorphisms in Hungarian patients with Crohn’s disease (CD). Four hundred sixty-eight CD patients and 384 healthy controls were examined. Hp phenotypes were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting of the sera. The frequency of the Hp1 allele was significantly higher in CD (0.395; OR, 1.24; 95% CI, 1.02–1.52; P=0.03) compared to controls (0.345). In CD, Hp phenotype was associated with disease behavior (OR [Hp2‐1 vs other], 2.06; 95% CI, 1.29–3.28 for inflammatory behavior). Furthermore, an increased frequency of primary sclerosing cholangitis was observed in the Hp 2-2 compared to the Hp 1-1 phenotype (6.5% vs. 0.0%; P=0.039). We conclude that the Hp polymorphism is associated with CD, inflammatory disease behavior, and primary sclerosing cholangitis in Hungarian patients. Further studies are required to evaluate the significance of Hp polymorphisms in other populations from geographically diverse regions.

Keywords

Haptoglobin polymorphism Crohn’s disease Disease behavior Th1/Th2 orientation Primary sclerosing cholangitis 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Maria Papp
    • 1
  • Peter Laszlo Lakatos
    • 2
  • Hungarian IBD Study Group
    • 1
  • Karoly Palatka
    • 1
  • Ildiko Foldi
    • 1
  • Miklos Udvardy
    • 3
  • Jolan Harsfalvi
    • 4
  • Istvan Tornai
    • 1
  • Zsuzsanna Vitalis
    • 1
  • Tamas Dinya
    • 5
  • Agota Kovacs
    • 6
  • Tamas Molnar
    • 7
  • Pal Demeter
    • 8
  • Janos Papp
    • 2
  • Laszlo Lakatos
    • 9
  • Istvan Altorjay
    • 1
  1. 1.Department of GastroenterologyUniversity of DebrecenDebrecenHungary
  2. 2.First Department of MedicineSemmelweis UniversityBudapestHungary
  3. 3.Department of HematologyUniversity of DebrecenDebrecenHungary
  4. 4.Clinical Research CenterUniversity of DebrecenDebrecenHungary
  5. 5.First Department of SurgeryUniversity of DebrecenDebrecenHungary
  6. 6.First Department of MedicineErzsebet HospitalBudapestHungary
  7. 7.First Department of MedicineUniversity of SzegedSzegedHungary
  8. 8.Department of GastroenterologySt. Margit HospitalBudapestHungary
  9. 9.First Department of MedicineCsolnoky F. County HospitalVeszpremHungary

Personalised recommendations