, Volume 52, Issue 12, pp 3507-3510
Date: 05 Apr 2007

The Beneficial Effect of N-Acetylcysteine and Ciprofloxacin Therapy on the Outcome of Ischemic Fulminant Hepatic Failure

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Case report

Fulminant hepatic failure (FHF) is a multisystemic disorder associated with high mortality rates [1]. The causes can be categorized broadly as viral, toxin-mediated, metabolic, autoimmune, ischemic, neoplastic, and idiopathic [2]. Because many FHF deaths result from impaired hepatic regeneration [3] and increased hepatocyte apoptosis [4], an appropriate treatment strategy would consist of medical intervention that either directly promotes hepatic regeneration or negates the effects of circulating inhibitors and prevents apoptosis [35].

Ischemic hepatitis refers to the development of centrilobular hepatic necrosis after a reduction in hepatic blood flow and is associated with a poor prognosis [6]. The high mortality rate of this disorder (about 60%) is related mainly to the underlying disease rather than the hepatitis itself [7]. In the absence of hypoxemia and prolonged shock, congestive heart failure (CHF) alone as a cause of FHF has been reported only in a very few patient ...