Digestive Diseases and Sciences

, Volume 52, Issue 2, pp 495–501

Effect of Acute Gastric Electrical Stimulation on the Systemic Release of Hormones and Plasma Glucose in Dogs

  • J. H. Xing
  • Y. Lei
  • H. R. Ancha
  • R. F. Harty
  • J. D. Chen
Original Article

DOI: 10.1007/s10620-006-9562-x

Cite this article as:
Xing, J.H., Lei, Y., Ancha, H.R. et al. Dig Dis Sci (2007) 52: 495. doi:10.1007/s10620-006-9562-x

Abstract

This study evaluated the effect of gastric electrical stimulation (GES) with various parameters on plasma concentrations of satiety-related peptides and glucose. GES was performed in nine healthy dogs via electrodes implanted in the middle of the lesser curvature. Four sessions were performed in each animal: control, stimulation with IGS (implantable gastric stimulation for obesity, 0.3 m sec), modified IGS (2 msec), and long pulses (300 msec). Blood samples were collected at 15 and 0 min before the meal and at 15, 30, and 60 min after the meal. GES was initiated 30 min before the first blood sample and maintained throughout collection. Plasma ghrelin, leptin, insulin and glucose were measured. The total AUCs of plasma ghrelin and leptin were not significantly affected by GES. The total AUC of plasma insulin was significantly lower with IGS and long pulse parameters (P < 0.05). The total AUC for plasma glucose was significantly lower in sessions with long pulses and modified IGS parameters (P < 0.05). We conclude that acute GES is able to change the release of some satiety-related peptides. Whether this is associated with the changed eating behavior and weight loss in obese patients needs further investigation.

Keywords

Gastric electrical stimulationGhrelinLeptinIInsulinGlucose

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • J. H. Xing
    • 1
  • Y. Lei
    • 1
  • H. R. Ancha
    • 1
  • R. F. Harty
    • 2
  • J. D. Chen
    • 1
    • 3
  1. 1.Veterans Research FoundationOklahoma CityUSA
  2. 2.Division of GastroenterologyOklahoma University Health Science CenterOklahoma CityUSA
  3. 3.Division of GastroenterologyUniversity of Texas Medical BranchGalvestonUSA