N-Acetyl-l-Glutamine, A Liquid-Stable Source of Glutamine, Partially Prevents Changes in Body Weight and on Intestinal Immunity Induced by Protein Energy Malnutrition in Pigs

  • José M. López-Pedrosa
  • Manuel Manzano
  • Jeffrey H. Baxter
  • Ricardo Rueda
Original Paper

DOI: 10.1007/s10620-006-9500-y

Cite this article as:
López-Pedrosa, J.M., Manzano, M., Baxter, J.H. et al. Dig Dis Sci (2007) 52: 650. doi:10.1007/s10620-006-9500-y

Abstract

The goal of this study was to evaluate the preventive effect of free glutamine versus N-acetyl-l-glutamine, a liquid-stable source of glutamine, on gut damage induced by protein energy malnutrition in pigs. Healthy pigs (n=6) were fed a liquid formula for 30 days. Three subgroups of malnourished pigs (n=6) received daily 20% of the food intake recorded in control group, supplemented with calcium caseinate, glutamine, or N-acetyl-l-glutamine. Body weight was recorded, and small intestinal samples were evaluated for biochemical and immunologic parameters. Suppression in body weight gain was significantly lower in pigs fed with N-acetyl-l-glutamine than in the rest of malnourished pigs. Total number of lymphocytes, CD21+ B cells and CD4+ T cells in ileal Peyer patches were not significantly different in malnourished pigs fed with N-acetyl-l-glutamine and in healthy pigs. In conclusion, N-acetyl-l-glutamine has a moderate protective effect, partially preventing changes induced by protein energy malnutrition.

Keywords

Glutamine N-acetyl-l-glutamine Pig Malnutrition Intestinal immunity 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • José M. López-Pedrosa
    • 1
  • Manuel Manzano
    • 1
  • Jeffrey H. Baxter
    • 2
  • Ricardo Rueda
    • 1
  1. 1.Strategic R&DAbbott Nutrition International, Abbott LaboratoriesGranadaSpain
  2. 2.Strategic Research, Ross Products DivisionAbbott LaboratoriesColumbusUSA

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