, Volume 52, Issue 9, pp 2078-2081
Date: 04 Apr 2007

Mucormycosis Presenting as Recurrent Gastric Perforation in a Patient with Crohn’s Disease on Glucocorticoid, 6-Mercaptopurine, and Infliximab Therapy

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access
This is an excerpt from the content

Mucormycosis is a rare opportunistic infection caused by fungi from the order Mucorales, which comprises 6 families that can cause varying infectious syndromes [1]. Rhizopus species is the most common organism implicated, but infections have been described with other fungi of the family Mucorales including absidia, mucor, rhizomucor, and cunninghamella [13]. Mucormycosis can present in a variety of anatomic locations including rhinocerebral, pulmonary, cutaneous, gastrointestinal, and disseminated disease depending on underlying host characteristics [1]. The infection was previously rare, with 1 study estimating an incidence of mucormycosis of 1.7 cases per million people per year, although it has been increasing in incidence in recent years [46].

We report a case of gastrointestinal mucormycosis that presented as recurrent gastric perforation in a patient with Crohn’s disease (CD) being treated with corticosteroids, 6-mercaptopurine (6 MP), and infliximab. This is the first descripti ...