Digestive Diseases and Sciences

, Volume 52, Issue 2, pp 589–593

The Effect of a Low-Carbohydrate, Ketogenic Diet on Nonalcoholic Fatty Liver Disease: A Pilot Study

Authors

  • David Tendler
    • Division of GastroenterologyDepartment of Medicine, Duke University Health System
  • Sauyu Lin
    • Division of GastroenterologyDepartment of Medicine, Duke University Health System
  • William S. YancyJr.
    • Division of General Internal MedicineDepartment of Medicine, Duke University Health System
    • Center for Health Services Research in Primary CareDepartment of Veterans’ Affairs Medical Center
  • John Mavropoulos
    • Division of General Internal MedicineDepartment of Medicine, Duke University Health System
  • Pam Sylvestre
    • Division of GastroenterologyDepartment of Medicine, Duke University Health System
  • Don C. Rockey
    • Division of GastroenterologyDepartment of Medicine, Duke University Health System
    • Division of General Internal MedicineDepartment of Medicine, Duke University Health System
    • Duke University Medical Center
Original Article

DOI: 10.1007/s10620-006-9433-5

Cite this article as:
Tendler, D., Lin, S., Yancy, W.S. et al. Dig Dis Sci (2007) 52: 589. doi:10.1007/s10620-006-9433-5

Abstract

Nonalcoholic fatty liver disease is an increasingly common condition that may progress to hepatic cirrhosis. This pilot study evaluated the effects of a low-carbohydrate, ketogenic diet on obesity-associated fatty liver disease. Five patients with a mean body mass index of 36.4 kg/m2 and biopsy evidence of fatty liver disease were instructed to follow the diet (<20 g/d of carbohydrate) with nutritional supplementation for 6 months. Patients returned for group meetings biweekly for 3 months, then monthly for the second 3 months. The mean weight change was −12.8 kg (range 0 to −25.9 kg). Four of 5 posttreatment liver biopsies showed histologic improvements in steatosis (P=.02) inflammatory grade (P=.02), and fibrosis (P=.07). Six months of a low-carbohydrate, ketogenic diet led to significant weight loss and histologic improvement of fatty liver disease. Further research is into this approach is warranted.

Keywords

Nonalcoholic fatty liver diseaseNASHLow-carbohydrate ketogenic dietCirrhosisFatty liver

Copyright information

© Springer Science+Business Media, Inc. 2007