Digestive Diseases and Sciences

, Volume 51, Issue 12, pp 2198–2205

Correlation of GLUT-1 Overexpression, Tumor Size, and Depth of Invasion with 18F-2-fluoro-2-deoxy-d-glucose Uptake by Positron Emission Tomography in Colorectal Cancer

  • Jinyu Gu
  • Hirofumi Yamamoto
  • Hiroki Fukunaga
  • Katsuki Danno
  • Ichiro Takemasa
  • Masataka Ikeda
  • Mitsuaki Tatsumi
  • Mitsugu Sekimoto
  • Jun Hatazawa
  • Tsunehiko Nishimura
  • Morito Monden
Original Paper

DOI: 10.1007/s10620-006-9428-2

Cite this article as:
Gu, J., Yamamoto, H., Fukunaga, H. et al. Dig Dis Sci (2006) 51: 2198. doi:10.1007/s10620-006-9428-2

Abstract

We investigated the wide variability of 18F-2-fluoro-2-deoxy-d-glucose (FDG) uptake, semiquantified as standardized uptake value (SUV), in positron emission tomography (PET) scanning, in 20 patients with colorectal cancer (CRC), including 1 with synchronous hepatic metastasis. The sensitivity of PET in CRC diagnosis was 100%, with a mean SUV of 8.0 (3.1–11.9). Tumor size and depth of invasion were associated with higher SUVs (P=.0004, .042, respectively). Strong glucose transporter-1 (GLUT-1) expression had significantly positive correlation with the SUV (r=.619, P=.003). GLUT-1 expression revealed positive staining in 17 (85%) of the 20 primary lesions. The central part of the tumor, thought to be relatively hypoxic, had stronger GLUT-1 expression and a higher SUV than the periphery, in both the primary tumor and hepatic metastatic foci. Our data suggest that the SUVs of FDG uptake in PET may be a noninvasive biomarker for advanced CRC, indicative of a large hypoxic tumor with deep invasion.

Keywords

Standardized uptake value 18F-2-fluoro-2-deoxy-d-glucose Positron emission tomography Colorectal cancer Glucose transporter-1 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Jinyu Gu
    • 1
    • 2
  • Hirofumi Yamamoto
    • 1
  • Hiroki Fukunaga
    • 1
  • Katsuki Danno
    • 1
  • Ichiro Takemasa
    • 1
  • Masataka Ikeda
    • 1
  • Mitsuaki Tatsumi
    • 3
  • Mitsugu Sekimoto
    • 1
  • Jun Hatazawa
    • 3
  • Tsunehiko Nishimura
    • 4
  • Morito Monden
    • 1
  1. 1.Department of Surgery and Clinical OncologyGraduate School of Medicine, Osaka UniversitySuita-CityJapan
  2. 2.Department of General SurgeryThe Second Affiliated Hospital of Harbin Medical UniversityHarbinChina
  3. 3.Department of Nuclear Medicine and Tracer KineticsGraduate School of Medicine, Osaka UniversityOsakaJapan
  4. 4.Department of RadiologyGraduate School of Medicine, Kyoto Prefectural University of MedicineKyotoJapan

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