Digestive Diseases and Sciences

, Volume 51, Issue 11, pp 1962–1966

Is Hepatitis C Virus Positivity a Contributing Factor to Occult Hepatitis B Virus Infection in Hemodialysis Patients?

Authors

    • Department of Internal MedicineBaskent University Faculty of Medicine
  • Gurden Gur
    • Department of Internal MedicineBaskent University Faculty of Medicine
  • Ali Akcay
    • Department of Internal MedicineBaskent University Faculty of Medicine
  • Haldun Selcuk
    • Department of GastroenterologyBaskent University Faculty of Medicine
  • Ugur Yilmaz
    • Department of GastroenterologyBaskent University Faculty of Medicine
  • Hande Arslan
    • Department of GastroenterologyBaskent University Faculty of Medicine
  • Sedat Boyacioglu
    • Department of GastroenterologyBaskent University Faculty of Medicine
  • Fatma Nurhan Ozdemir
    • Department of NephrologyBaskent University Faculty of Medicine
Original Article

DOI: 10.1007/s10620-006-9421-9

Cite this article as:
Kanbay, M., Gur, G., Akcay, A. et al. Dig Dis Sci (2006) 51: 1962. doi:10.1007/s10620-006-9421-9

Abstract

Hepatitis B (HBV) infections continue to occur in adult hemodialysis units. Occult HBV infection (serum hepatitis B surface antigen [HBsAg] negative but HBV DNA positive) may be a contributing factor in these patients. This study was designed to (1) investigate the prevalence of occult HBV infection in hemodialysis patients and (2) compare the prevalence of occult HBV infection among hepatitis C (HCV)-positive and HCV-negative hemodialysis patients. The study included 138 patients on chronic hemodialysis. Eighty-four patients were HCV positive and 54 were HCV negative. HBV DNA testing was performed by polymerase chain reaction. We also recorded general characteristics of the patients, duration of hemodialysis, and serum alanine aminotransferase and aspartate aminotransferase levels. Twenty-one (15.2%) of the 138 hemodialysis patients were HBV DNA positive. Nine (16.6%) of the 54 anti-HCV antibody negative hemodialysis patients were HBV DNA positive. Twelve (14.2%) of the 84 anti-HCV antibody positive patients were HBV DNA positive. The prevalence in anti-HCV Ab positive and negative hemodialysis patients were same (P > .05). Hemodialysis duration, demographic features, and biochemical parameters were not significantly different in patients with and without occult HBV infection in both HCV-positive and -negative hemodialysis patients (P > .05). HCV positivity is not a contributing factor to occult HBV infection in hemodialysis patients. None of the parameters tested help to distinguish patients with occult HBV infection from those who are HBV DNA negative.

Keywords

Occult HBV infectionHemodialysisHCV infection

Copyright information

© Springer Science+Business Media, Inc. 2006