Original Paper

Digestive Diseases and Sciences

, Volume 52, Issue 4, pp 967-972

First online:

Biochemical Markers of Bone Metabolism in Children with Helicobacter pylori Infection

  • Sebahat OzdemAffiliated withCentral Laboratory, Clinical Biochemistry Unit, Akdeniz University, Medical Faculty Email author 
  • , Mustafa AkcamAffiliated withDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Akdeniz University, Medical Faculty
  • , Aygen YilmazAffiliated withDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Akdeniz University, Medical Faculty
  • , Meral GultekinAffiliated withDepartment of Microbiology, Akdeniz University, Medical Faculty
  • , Reha ArtanAffiliated withDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Akdeniz University, Medical Faculty

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Abstract

We investigated the biochemical markers of bone metabolism in children with Helicobacter pylori infection. Biochemical markers of bone metabolism and serum levels of vitamin B12, ferritin and estradiol were measured in 41 H. pylori-positive (+) children (23 girls, 18 boys; aged 11.8±3 years). Serum levels of intact parathyroid hormone, ß-collagen I carboxy terminal telopeptide, total alkaline phosphatase (ALP), bone-specific ALP, N-terminal cross-links of human procollagen type I, N-mid-osteocalcin, calcium, phosphate, ferritin, and estradiol did not differ significantly between H. pylori(+) and H. pylori negative (−) children. Vitamin B12 levels were significantly decreased in H. pylori(+) compared to H. pylori(−) children. H. pylori infection was not accompanied by significant changes in markers of bone metabolism in children, although vitamin B12 levels were decreased. Further studies are required to clarify whether H. pylori infection causes time-dependent changes in bone turnover markers during the long course of this inflammatory disease.

Keywords

Bone markers Children Ferritin Helicobacter pylori Osteoporosis Vitamin B12