Review Article

Digestive Diseases and Sciences

, Volume 52, Issue 8, pp 1752-1756

Spontaneous Intestinal Perforation Due to Non-Hodgkin's Lymphoma: Evaluation of Eight Cases

  • Cengiz AraAffiliated withDepartment of General Surgery, Inonu University School of Medicine Email author 
  • , Sacid CobanAffiliated withDepartment of General Surgery, Inonu University School of Medicine
  • , Cuneyt KayaalpAffiliated withDepartment of General Surgery, Inonu University School of Medicine
  • , Sezai YilmazAffiliated withDepartment of General Surgery, Inonu University School of Medicine
  • , Vedat KirimliogluAffiliated withDepartment of General Surgery, Inonu University School of Medicine

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Abstract

Primary intestinal lymphoma with spontaneous perforation and after systemic chemotherapy is rare. The present study summarizes retrospectively the outcome of eight free intestinal perforated patients diagnosed with intestinal non-Hodgkin's lymphoma. Two patients had a history of systemic chemotherapy before perforation. The most common symptoms of the patients were abdominal pain, nausea, vomiting, weight loss, and fever. Sites of perforation were ileum in four, jejunum in two, cecum in one, and sigmoid colon in one patient. Synchronous lymphoma was present in three patients. The perforation was closed by primary closure in three patients. Resection/anastomosis was performed in four patients and sigmoid colostomy was performed in one patient. Three patients were lost due to leakage or septicemia. Intestinal lymphoma might be kept in mind as a cause in free intestinal perforations. Because of the high mortality rate early diagnosis and treatment are important to improve the prognosis of bowel perforation in patients with non-Hodgkin's lymphoma.

Keywords

Intestinal lymphoma Perforation Chemotherapy Treatment