Digestive Diseases and Sciences

, Volume 52, Issue 8, pp 1798–1805

Prescribing Patterns and Awareness of Adverse Effects of Infliximab: A Health Survey of Gastroenterologists

  • Meaghan Donovan
  • Kevin Lunney
  • Olivia Carter-Pokras
  • Raymond K. Cross
Original Paper

DOI: 10.1007/s10620-006-9269-z

Cite this article as:
Donovan, M., Lunney, K., Carter-Pokras, O. et al. Dig Dis Sci (2007) 52: 1798. doi:10.1007/s10620-006-9269-z

Abstract

We sought to determine prescribing patterns and awareness of adverse drug reactions to infliximab among gastroenterologists. A questionnaire was developed and mailed to all gastroenterologists in Maryland and Washington, D.C. Ninety-six of 336 (28.6%) gastroenterologists responded; 86% of respondents use infliximab often or sometimes and 48% infuse infliximab on-site. Only 48% of respondents use immunomodulators prior to infusing infliximab. Thirty-three percent of respondents do not prescribe maintenance infliximab. Respondents reported that infusion reactions occur in 12.9% of infliximab infusions. Most respondents order a purified protein derivative prior to starting infliximab. Respondents underestimated the risk of serious infection, death, demyelinating diseases, and malignancy and overestimated the risk of congestive heart failure. We conclude that a substantial number of gastroenterologists underutilize immunomodulators and fail to prescribe maintenance infliximab. Further, respondents were unaware of the frequency of major adverse events associated with infliximab. Education regarding treatment algorithms in CD and infliximab-related side effects is needed.

Keywords

Infliximab Antibodies Monoclonal Drug therapy Adverse effects 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Meaghan Donovan
    • 1
  • Kevin Lunney
    • 2
  • Olivia Carter-Pokras
    • 2
  • Raymond K. Cross
    • 3
    • 4
  1. 1.Department of Pharmaceutical Health Services ResearchUniversity of Maryland School of PharmacyBaltimoreUSA
  2. 2.Department of Epidemiology and Preventive MedicineUniversity of Maryland School of MedicineBaltimoreUSA
  3. 3.Department of Medicine, Division of Gastroenterology and HepatologyUniversity of Maryland School of Medicine, and Veterans Affairs, Maryland Heath Care SystemBaltimoreUSA
  4. 4.Division of Gastroenterology and HepatologyUniversity of Maryland Medical Center, 22 South Greene Street, N3W62BaltimoreUSA

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