Digestive Diseases and Sciences

, Volume 51, Issue 11, pp 1992–1997

The Significance of the Furosemide Test for Predicting Ascites Control by Diuretics in Cirrhotics: A Comparison with Volume Expansion and Octreotide Infusion

  • Pierluigi Toniutto
  • Mario Pirisi
  • Carlo Fabris
  • Luca Apollonio
  • Kalliopi Sereti
  • Ettore G. Bartoli
Original Paper

DOI: 10.1007/s10620-005-9072-2

Cite this article as:
Toniutto, P., Pirisi, M., Fabris, C. et al. Dig Dis Sci (2006) 51: 1992. doi:10.1007/s10620-005-9072-2

Abstract

To verify prospectively the usefulness of the furosemide-induced natriuresis test in predicting ascites control by medical treatment, 15 stable cirrhotics (9 male) with ascites were studied. Sodium excretion was measured after this test and after volume expansion with saline associated with intravenous infusion of octreotide; 6 months later, response to medical treatment was rated as good (N=9) or poor (N=6). Patients with poor ascites control had lower sodium excretion with the furosemide-induced natriuresis test (median, 88 vs 201 mmol; P < 0.01). Poor control was observed in four of four patients with sodium excretion ≤125 mmol, and good control in six of six patients with sodium excretion >175 mmol (P < 0.002). Volume expansion was followed by limited natriuresis (median, 20 mmol), in inverse relationship with plasma active renin concentration (P < 0.001). In conclusion, long-term ascites control is well predicted by the furosemide-induced natriuresis test.

Keywords

Ascites Cirrhosis Furosemide Octreotide Plasma volume 

Copyright information

© Springer Science+Bisiness Media, Inc. 2006

Authors and Affiliations

  • Pierluigi Toniutto
    • 1
  • Mario Pirisi
    • 2
    • 3
  • Carlo Fabris
    • 1
  • Luca Apollonio
    • 1
  • Kalliopi Sereti
    • 2
  • Ettore G. Bartoli
    • 2
  1. 1.Department of Experimental and Clinical Pathology—Medicine (DPMSC)University of UdineUdineItaly
  2. 2.Department of Medical SciencesUniversity of Eastern Piedmont “A. Avogadro”NovaraItaly
  3. 3.Dipartimento di Scienze MedicheUniversità del Piemonte Orientale “A. Avogadro”Novara (NO)Italy

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