Digestive Diseases and Sciences

, Volume 51, Issue 10, pp 1712–1715

Brief Report: No Evidence for Parvovirus B19 or Hepatitis E Virus as a Cause of Acute Liver Failure

  • W. M. Lee
  • K. E. Brown
  • N. S. Young
  • G. J. Dawson
  • G. G. Schlauder
  • R. A. Gutierrez
  • R. Fontana
  • L. Rossaro
  • T. Davern
  • E. Lalani
  • Acute Liver Failure Study Group (ALFSG)
Original Article

DOI: 10.1007/s10620-005-9061-5

Cite this article as:
Lee, W.M., Brown, K.E., Young, N.S. et al. Dig Dis Sci (2006) 51: 1712. doi:10.1007/s10620-005-9061-5

Abstract

Viral hepatitis A and B are known to cause acute liver failure. While nearly 20% of acute liver failure cases are of indeterminate etiology, screening for other viruses has not been uniformly performed. We looked for evidence for parvovirus B19 and hepatitis E virus in sera from U.S. acute liver failure patients. For B19, 78 patients’ sera, including 34 with indeterminate etiology, were evaluated by DNA dot-blot hybridization, reverse transcription polymerase chain reaction, and enzyme-linked immunosorbent assay for immunoglobin G and M antibodies; none showed evidence for infection. In like manner, 126 patients’ sera were analyzed for hepatitis E virus RNA by reverse transcription polymerase chain reaction and for hepatitis E virus immunoglobin G and M antibodies by enzyme-linked immunosorbent assay; no acute hepatitis E virus cases were identified. If a unique acute liver failure virus exists, it is neither of these candidate agents.

Keywords

Parvovirus B19 Hepatitis E virus Acute liver failure Encephalopathy Polymerase chain reaction 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • W. M. Lee
    • 1
  • K. E. Brown
    • 2
  • N. S. Young
    • 2
  • G. J. Dawson
    • 3
  • G. G. Schlauder
    • 3
  • R. A. Gutierrez
    • 3
  • R. Fontana
    • 4
  • L. Rossaro
    • 5
  • T. Davern
    • 6
  • E. Lalani
    • 1
  • Acute Liver Failure Study Group (ALFSG)
  1. 1.Division of Digestive and Liver DiseasesUniversity of Texas Southwestern Medical CenterDallasUSA
  2. 2.National Heart, Lung and Blood InstituteBethesdaUSA
  3. 3.Abbott LaboratoriesAbbott ParkUSA
  4. 4.University of MichiganAnn ArborMichiganUSA
  5. 5.University of California at DavisDavisUSA
  6. 6.University of California at San FranciscoSan FranciscoUSA

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