Digestive Diseases and Sciences

, Volume 51, Issue 10, pp 1712–1715

Brief Report: No Evidence for Parvovirus B19 or Hepatitis E Virus as a Cause of Acute Liver Failure


    • Division of Digestive and Liver DiseasesUniversity of Texas Southwestern Medical Center
  • K. E. Brown
    • National Heart, Lung and Blood Institute
  • N. S. Young
    • National Heart, Lung and Blood Institute
  • G. J. Dawson
    • Abbott Laboratories
  • G. G. Schlauder
    • Abbott Laboratories
  • R. A. Gutierrez
    • Abbott Laboratories
  • R. Fontana
    • University of Michigan
  • L. Rossaro
    • University of California at Davis
  • T. Davern
    • University of California at San Francisco
  • E. Lalani
    • Division of Digestive and Liver DiseasesUniversity of Texas Southwestern Medical Center
  • Acute Liver Failure Study Group (ALFSG)
Original Article

DOI: 10.1007/s10620-005-9061-5

Cite this article as:
Lee, W.M., Brown, K.E., Young, N.S. et al. Dig Dis Sci (2006) 51: 1712. doi:10.1007/s10620-005-9061-5


Viral hepatitis A and B are known to cause acute liver failure. While nearly 20% of acute liver failure cases are of indeterminate etiology, screening for other viruses has not been uniformly performed. We looked for evidence for parvovirus B19 and hepatitis E virus in sera from U.S. acute liver failure patients. For B19, 78 patients’ sera, including 34 with indeterminate etiology, were evaluated by DNA dot-blot hybridization, reverse transcription polymerase chain reaction, and enzyme-linked immunosorbent assay for immunoglobin G and M antibodies; none showed evidence for infection. In like manner, 126 patients’ sera were analyzed for hepatitis E virus RNA by reverse transcription polymerase chain reaction and for hepatitis E virus immunoglobin G and M antibodies by enzyme-linked immunosorbent assay; no acute hepatitis E virus cases were identified. If a unique acute liver failure virus exists, it is neither of these candidate agents.


Parvovirus B19Hepatitis E virusAcute liver failureEncephalopathyPolymerase chain reaction

Copyright information

© Springer Science+Business Media, Inc. 2006