Digestive Diseases and Sciences

, Volume 51, Issue 10, pp 1862–1868

Increased Protein Expression of Matrix Metalloproteinases -1, -3, and -9 and TIMP-1 in Patients with Gluten-Sensitive Enteropathy

  • Bashir M. Mohamed
  • Conleth Feighery
  • Jacinta Kelly
  • Christian Coates
  • Una O’Shea
  • Louise Barnes
  • Mohamed Abuzakouk
Original Paper

DOI: 10.1007/s10620-005-9038-4

Cite this article as:
Mohamed, B.M., Feighery, C., Kelly, J. et al. Dig Dis Sci (2006) 51: 1862. doi:10.1007/s10620-005-9038-4

Abstract

Gluten-sensitive enteropathy is characterized by small intestinal damage. The pathogenic mechanisms involved are not precisely understood. There is recent interest in the possibility that matrix metalloproteinases might play a pathogenic role. Using immunohistochemistry technique, we examined the protein expression of matrix metalloproteinases-1, -3, and -9 and the tissue inhibitor metalloproteinase-1 in duodenal biopsies from 30 patients with celiac disease and dermatitis herpetiformis. We demonstrated that the percentage of cells expressing these enzymes and their inhibitor in all patients was significantly greater than in the normal controls (P < 0.0001). This was evident even in patients with a minimal lesion but was most marked in patients with severe damage, mirroring the degree of inflammation in the small intestinal tissue. The increased expression of these enzymes and their inhibitor in the duodenal mucosa of patients with gluten-sensitive enteropathy suggests a role for these enzymes in the tissue remodeling which is a feature of these disorders.

Keywords

Celiac diseaseDermatitis herpetiformisMatrix metalloproteinasesGluten-sensitive enteropathy

Copyright information

© Springer Science&#x002B;Business Media, Inc. 2006

Authors and Affiliations

  • Bashir M. Mohamed
    • 1
  • Conleth Feighery
    • 1
  • Jacinta Kelly
    • 3
  • Christian Coates
    • 1
  • Una O’Shea
    • 1
  • Louise Barnes
    • 2
  • Mohamed Abuzakouk
    • 1
    • 4
  1. 1.Department of ImmunologySt. James’s Hospital, Trinity College and Dublin Molecular Medicine CenterDublinIreland
  2. 2.Department of DermatologySt. James’s HospitalDublinIreland
  3. 3.Dublin Institute of TechnologyDublinIreland
  4. 4.Department of ImmunologySt. James’s Hospital and Trinity College DublinDublin 8Ireland