Digestive Diseases and Sciences

, Volume 51, Issue 9, pp 1571–1581

Ketamine-Induced Gastroprotection During Endotoxemia: Role of Heme-Oxygenase-1

  • Kenneth S. Helmer
  • James W. Suliburk
  • David W. Mercer
Original Paper

DOI: 10.1007/s10620-005-9013-0

Cite this article as:
Helmer, K.S., Suliburk, J.W. & Mercer, D.W. Dig Dis Sci (2006) 51: 1571. doi:10.1007/s10620-005-9013-0

Abstract

Inducible nitric oxide synthase contributes to lipopolysacharide-induced gastric injury. In contrast, heme-oxygenase-1 has anti-inflammatory effects and is protective against oxidative tissue injury. Ketamine attenuates injury from lipopolysacharide and is associated with changes in oxidative stress proteins, but its effects on the stomach remain to be fully elucidated. We hypothesized that ketamine would diminish gastric injury from lipopolysacharide via down-regulation of nuclear factor-κß, activator protein-1, and inducible nitric oxide synthase, as well as up-regulation of heme-oxygenase-1. Ketamine up-regulated heme-oxygenase-1 and attenuated lipopolysacharide-induced changes in gastric nuclear factor-κß, activator protein-1, and inducible nitric oxide synthase. Ketamine negated LPS-induced gastric injury from acidified ethanol, an effect reversed by tin protoporphorin IX. Ketamine diminishes the susceptibility of gastric mucosa to damage from luminal irritants during endotoxemia, which is mediated in part by down-regulation of iNOS and up-regulation of HO-1.

Key Words

Gastric injury Lipopolysacharide Mild irritants Nitric oxide synthase Heme-oxygenase HO-1 NF-κß AP-1 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Kenneth S. Helmer
    • 1
  • James W. Suliburk
    • 1
  • David W. Mercer
    • 1
    • 2
  1. 1.Department of SurgeryUniversity of Texas Medical SchoolHoustonUSA
  2. 2.UT-Houston Medical School/LBJ General HospitalHoustonUSA

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