Digestive Diseases and Sciences

, Volume 50, Issue 12, pp 2323–2329

Efficacy of Rebamipide Enemas in Active Distal Ulcerative Colitis and Proctitis: A Prospective Study Report

Article

DOI: 10.1007/s10620-005-3055-1

Cite this article as:
Makiyama, K., Takeshima, F. & Hamamoto, T. Dig Dis Sci (2005) 50: 2323. doi:10.1007/s10620-005-3055-1
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Abstract

Rebamipide has a broad spectrum of pharmacological actions that include suppression of neutrophil functions and stimulation of mucosal epithelial cell regeneration by increasing the expression of epithelial growth factor (EGF) and the EGF receptor. Sixteen patients with active ulcerative colitis (UC; mild in 1 patient, moderate in 11, and severe in 4) were recruited. Enemas containing 150 mg rebamipide per dosing were administered during the daytime after passage of stool, twice a day for 4 weeks. UC disease activity index (UC-DAI), endoscopic activity index (EAI), and Floren's grading (FG) of mucosal biopsy specimens were measured at entry and at 4 weeks. Five of 16 patients did not complete the study, and therefore, final efficacy assessment was done on 11 patients who completed the 4 weeks of treatment. Improvements were observed in UC-DAI (P= 0.0049), EAI (P= 0.0043), and FG (P= 0.0084). There was no serious rebamipide-related side effect in any of the 16 patients. In conclusion, rebamipide topical therapy appears to be effective for the treatment of mildly to moderately active distal UC. Further controlled studies are warranted for this promising drug.

KeyWords

distal ulcerative colitisrebamipidetopical therapy

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  1. 1.Department of EndoscopyNagasaki University Hospital of Medicine and DentistryNagasakiJapan
  2. 2.Department of General MedicineNagasaki University Hospital of Medicine and DentistryNagasakiJapan
  3. 3.Department of Hospital PharmacyNagasaki University Hospital of Medicine and DentistryNagasakiJapan
  4. 4.Department of EndoscopyNagasaki University Hospital of Medicine and DentistryNagasakiJapan