Digestive Diseases and Sciences

, Volume 50, Issue 12, pp 2263–2267

A Possible Role of GLP-1 in the Pathophysiology of Early Dumping Syndrome

  • Hiroshi Yamamoto
  • Tsuyoshi Mori
  • Hiroshi Tsuchihashi
  • Hiroya Akabori
  • Hiroyuki Naito
  • Tohru Tani
Article

DOI: 10.1007/s10620-005-3046-2

Cite this article as:
Yamamoto, H., Mori, T., Tsuchihashi, H. et al. Dig Dis Sci (2005) 50: 2263. doi:10.1007/s10620-005-3046-2

Abstract

Exaggerated plasma concentrations of GLP-1 precede reactive hypoglycemia after oral glucose in gastrectomy patients, resulting in late dumping syndrome. Recently, we showed that GLP-1 elicits the activation of sympathetic outflow. Because sympathetic activation is thought to be a cause of early dumping, we hypothesized that exaggerated GLP-1 may contribute to the pathophysiology of early dumping syndrome. In 11 patients after gastrectomy and 14 controls, blood pressure, heart rate, and plasma concentrations of norepinephrine, epinephrine, GLP-1, glucagon, insulin, and glucose were measured after oral glucose. In gastrectomy patients, GLP-1, norepinephrine, and heart rate peaked 15 to 30 min after oral glucose. Significant positive correlations were found among GLP-1, norepinephrine, and heart rate at 30 min, and these parameters at 30 min were significantly higher in patients with early dumping syndrome. These results suggest that GLP-1 is involved in the pathophysiology of early dumping syndrome.

KeyWords

dumping syndromeGLP-1norepinephrinesympatheticinsulin

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Hiroshi Yamamoto
    • 1
    • 2
  • Tsuyoshi Mori
    • 1
  • Hiroshi Tsuchihashi
    • 1
  • Hiroya Akabori
    • 1
  • Hiroyuki Naito
    • 1
  • Tohru Tani
    • 1
  1. 1.The Department of SurgeryShiga University of Medical ScienceShigaJapan
  2. 2.Department of SurgeryShiga University of Medical ScienceShigaJapan