Digestive Diseases and Sciences

, Volume 50, Issue 12, pp 2224–2230

CD54 Expression Is Predictive for Lymphatic Spread in Human Gastric Carcinoma


DOI: 10.1007/s10620-005-3039-1

Cite this article as:
Yashiro, M., Sunami, T. & Hirakawa, K. Dig Dis Sci (2005) 50: 2224. doi:10.1007/s10620-005-3039-1


Even among gastric carcinoma cases with a similar extent of lymphatic invasion, the number of diseased lymph nodes may vary. Other factors might also contribute to the process of lymphangitic metastasis. Primary gastric tumors with the same extent of pathologic lymphatic invasion were studied in 78 patients. We investigated the correlation between CD54 expression on cancer cells and clinicopathologic features. Decreased CD54 expression on cancer cells was significantly correlated with the number of involved lymph nodes and the extent of lymph node spread. The number of diseased lymph nodes was associated with the prognosis of patients with gastric carcinoma. The CD54-negative group had a significantly worse prognosis than the CD54-positive group. These findings suggested that CD54 expression is predictive for lymphatic spread and prognosis in human gastric carcinoma.


CD54 gastric cancer lymph node metastasis predictive factor 

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Masakazu Yashiro
    • 1
  • Takeshi Sunami
    • 1
  • Kosei Hirakawa
    • 1
  1. 1.The Department of Surgical OncologyOsaka City University Graduate School of MedicineOsakaJapan