Digestive Diseases and Sciences

, Volume 50, Issue 11, pp 2009–2018

Efficacy of Rabeprazole in the Treatment of Symptomatic Gastroesophageal Reflux Disease

  • Peter J. Kahrilas
  • Philip Miner
  • John Johanson
  • Lian Mao
  • Leonard Jokubaitis
  • Sheldon Sloan
Article

DOI: 10.1007/s10620-005-3000-3

Cite this article as:
Kahrilas, P.J., Miner, P., Johanson, J. et al. Dig Dis Sci (2005) 50: 2009. doi:10.1007/s10620-005-3000-3

Abstract

The purpose of this study was to assess the rapidity of symptom relief and 4-week efficacy of rabeprazole 20 mg in patients with moderately severe nonerosive gastroesophageal reflux disease. Data were analyzed from 2 similarly designed, double-blind, placebo-controlled, multicenter, U.S. trials. After a 2-week placebo run-in period, patients (N = 261) were randomized to 4 weeks of rabeprazole 20 mg once daily or placebo. Patients kept symptom diaries and scored symptom severity. Median time to first 24-hour heartburn-free interval was 3.5 days for the rabeprazole group compared with 19.5 days for the placebo group (P ≤ .0002). Complete heartburn relief at week 4 was 32% with rabeprazole and 3.8% with placebo (P ≤ .001). Rabeprazole also significantly improved other GERD-associated symptoms (e.g., regurgitation, belching, early satiety) by week 4 compared with placebo (P ≤ .05). Rabeprazole provides fast and potent relief from heartburn and other symptoms of nonerosive gastroesophageal reflux disease.

Keywords

gastroesophageal reflux disease symptoms nonerosive gastroesophageal reflux disease proton pump inhibitor rabeprazole 

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Peter J. Kahrilas
    • 1
    • 5
  • Philip Miner
    • 2
  • John Johanson
    • 3
  • Lian Mao
    • 4
  • Leonard Jokubaitis
    • 4
  • Sheldon Sloan
    • 5
  1. 1.Northwestern University Feinberg School of MedicineChicago
  2. 2.Oklahoma Foundation for Digestive ResearchOklahoma City
  3. 3.Rockford Gastroenterology AssociatesRockford
  4. 4.Janssen Pharmaceutica Inc.Titusville
  5. 5.Section of GastroenterologyChicago

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