Digestive Diseases and Sciences

, Volume 50, Issue 9, pp 1654–1660

Relationships Between Gastric Accommodation and Gastrointestinal Sensations in Healthy Volunteers. A Study Using the Barostat Technique and Two- and Three-Dimensional Ultrasonography

  • M. W. Mundt
  • T. Hausken
  • A. J. P. M. Smout
  • M. Samsom
Article

DOI: 10.1007/s10620-005-2911-3

Cite this article as:
Mundt, M.W., Hausken, T., Smout, A.J.P.M. et al. Dig Dis Sci (2005) 50: 1654. doi:10.1007/s10620-005-2911-3

Abstract

The origin of postprandial gastrointestinal sensations and their relation to gastric accommodation remain unclear. Our aim was to investigate the relation between antral and fundal accommodation and sensations. (A) In eight healthy volunteers fundus accommodation was measured using a barostat after a 200-ml (300-kcal) liquid nutrient. Antral area (AA) was measured using ultrasound. Data on bag volumes, AA, and sensations were assessed. (B) In another eigth healthy volunteers gastric volume was measured after a 500-ml (300-kcal) liquid nutrient using 2-D/3-D ultrasound. Sensations were scored using VAS. Distal and proximal volumes were calculated from 3-D datasets. (A) Fullness was correlated with AA (r = 0.48, P = 0.002). Fullness and bag volume were not correlated. (B) Fullness was correlated with AA (r = 0.77, P < 0.001) and distal volume (r = 0.75, P < 0.001). Proximal volume was not correlated with fullness (r = 0.10, P = NS). We conclude that fullness is related to antral volume and area rather than proximal volume. The gastric antrum may play a key role in normal appetite regulation.

Keywords

three-dimensional ultrasonographygastric volumebarostatgastric accommodation

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • M. W. Mundt
    • 1
  • T. Hausken
    • 2
  • A. J. P. M. Smout
    • 1
  • M. Samsom
    • 1
    • 3
  1. 1.Gastrointestinal Research Unit, Departments of Gastroenterology and SurgeryUniversity Medical CenterUtrechtThe Netherlands
  2. 2.Division of Gastroenterology, Medical DepartmentUniversity of BergenBergenNorway
  3. 3.Gastrointestinal Research Unit, Department of Gastroenterology and HepatologyUniversity Medical Center UtrechtUtrechtThe Netherlands