Digestive Diseases and Sciences

, Volume 50, Issue 7, pp 1194–1201

The Efficacy of High- and Low-Dose Intravenous Omeprazole in Preventing Rebleeding for Patients with Bleeding Peptic Ulcers and Comorbid Illnesses

  • Hsiu-chi Cheng
  • Ai-wen Kao
  • Chiao-hsiung Chuang
  • Bor-shyang Sheu
Article

DOI: 10.1007/s10620-005-2759-6

Cite this article as:
Cheng, H., Kao, A., Chuang, C. et al. Dig Dis Sci (2005) 50: 1194. doi:10.1007/s10620-005-2759-6

Abstract

This study sought to determine if high-dose omeprazole infusion could improve the control of rebleeding in patients with comorbid illnesses and bleeding peptic ulcers. After achieving hemostasis by endoscopy, 105 patients were randomized into high-dose (n = 52) and low-dose (n = 53) groups, receiving 200 and 80 mg/day omeprazole, respectively, as a continuous infusion for 3 days.

Thereafter, oral omeprazole, 20 mg/day, was given. The cumulative rebleeding rates comparatively rose in both groups (high-dose vs. low-dose group), beginning on day 3 (15.4% vs. 11.3%), day 7 (19.6% vs. 20%), and day 14 (32.7% vs. 28.9%), until day 28 (35.4% vs. 33.3%), and were not significantly different between the two groups (P > 0.50). Multiple logistic regression confirmed that a serum albumin level < 3 g/dL was an independent factor associated with rebleeding (P = 0.002). For patients with comorbidities, 3-day omeprazole infusion, despite increasing the daily dose from 80 to 200 mg, was not adequate to control peptic ulcer rebleeding.

Key Words

peptic ulcer bleeding comorbid illnesses omeprazole infusion hypoalbuminemia 

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Hsiu-chi Cheng
    • 1
    • 2
  • Ai-wen Kao
    • 1
  • Chiao-hsiung Chuang
    • 1
  • Bor-shyang Sheu
    • 1
    • 2
    • 3
  1. 1.Department of Internal MedicineNational Cheng Kung University HospitalTainan
  2. 2.Institute of Clinical MedicineNational Cheng Kung University HospitalTainan
  3. 3.Department of Internal MedicineNational Cheng Kung University HospitalTainan