Digestive Diseases and Sciences

, Volume 50, Issue 6, pp 1052–1057

High Prevalence of Hypothyroidism in Patients with Autoimmune Pancreatitis

Authors

  • Kenichi Komatsu
    • Department of Medicine, GastroenterologyShinshu University School of Medicine
  • Hideaki Hamano
    • Department of Medicine, GastroenterologyShinshu University School of Medicine
  • Yasuhide Ochi
    • Department of Medicine, GastroenterologyShinshu University School of Medicine
  • Mari Takayama
    • Department of Medicine, GastroenterologyShinshu University School of Medicine
  • Takashi Muraki
    • Department of Medicine, GastroenterologyShinshu University School of Medicine
  • Kaname Yoshizawa
    • Department of Medicine, GastroenterologyShinshu University School of Medicine
  • Akihiro Sakurai
    • Division of Molecular Genetics, Department of Preventive MedicineShinshu University School of Medicine
  • Masao Ota
    • Department of Legal MedicineShinshu University School of Medicine
    • Department of Medicine, GastroenterologyShinshu University School of Medicine
    • Department of Medicine, GastroenterologyShinshu University School of Medicine
Article

DOI: 10.1007/s10620-005-2703-9

Cite this article as:
Komatsu, K., Hamano, H., Ochi, Y. et al. Dig Dis Sci (2005) 50: 1052. doi:10.1007/s10620-005-2703-9

Abstract

Autoimmune pancreatitis is a unique form of chronic pancreatitis and has been correlated with various extrapancreatic lesions. To search for a correlation between autoimmune pancreatitis and thyroid lesions, we measured thyroid functions in 41 patients with autoimmune pancreatitis and in 41 patients with chronic calcifying pancreatitis and investigated the correlation between HLA antigens and hypothyroidism. We found a significant difference in the prevalence of antithyroglobulin antibody and hypothyroidism between patients with autoimmune pancreatitis and those with chronic pancreatitis (34.1 vs. 7.3%, P = 0.005, and 26.8 vs. 0%, P = 0.0005, respectively). Patients with hypothyroidism had a significantly higher frequency of antithyroglobulin antibody (63.6%) than those without hypothyroidism but showed no differences in other findings, including serum IgG4 concentration. We could find no significant association between any HLA antigens and the hypothyroid state of autoimmune pancreatitis. One quarter of the patients with autoimmune pancreatitis have hypothyroidism that may be independent of the active state of the pancreatic lesion or systemic fibrosing disorder, and thus patients suspected of having autoimmune pancreatitis should be evaluated for possible hypothyroidism.

Key Words

autoimmune pancreatitishypothyroidismIgG4HLA

Copyright information

© Springer Science + Business Media, Inc. 2005