, Volume 57, Issue 2, pp 181-185
Date: 10 May 2008

Restraint stress up-regulates expression of zinc transporter Zip14 mRNA in mouse liver

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Abstract

The zinc concentration in the liver was significantly higher in mice at 12 h after the onset of restraint stress than that without stress. The IL-6 protein level in the serum was transiently elevated at 3 h after the onset of restraint stress, and the IL-6-responsive zinc transporter Zip14 mRNA in the liver was expressed markedly at 6 h. These results suggest that Zip14 plays a major role in the mechanism responsible for accumulation of zinc in the liver under restraint stress.