, Volume 53, Issue 1, pp 55–63

MicroRNAs: recently discovered key regulators of proliferation and apoptosis in animal cells

Identification of miRNAs regulating growth and survival
NICB special issue

DOI: 10.1007/s10616-007-9049-4

Cite this article as:
Gammell, P. Cytotechnology (2007) 53: 55. doi:10.1007/s10616-007-9049-4


The relatively recent discovery of miRNAs has added a completely new dimension to the study of the regulation of gene expression. The mechanism of action of miRNAs, the conservation between diverse species and the fact that each miRNA can regulate a number of targets and phenotypes clearly indicates the importance of these molecules. In this review the current state of knowledge relating to miRNA expression and gene regulation is presented, outlining the key morphological and biochemical features controlled by miRNAs with particular emphasis on the key phenotypes that impact on cell growth in bioreactors, namely proliferation and apoptosis.


MiRNAs Mammalian cell culture Apoptosis Proliferation 

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  1. 1.National Institute for Cellular Biotechnology, Dublin City UniversityDublinIreland

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