, Volume 48, Issue 5, pp 889-890
Date: 17 Nov 2012

Constituents of Scutellaria holosericea

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Plants of the genus Scutellaria L. (Lamiaceae) are one source of flavonoids in the flora of Uzbekistan. Flavonoids represent the most numerous class of natural phenolic compounds and typically have varied structures, high and multi-faceted activities, and low toxicities.

Scutellaria holosericea Gontsch ex Juz [1] is a perennial endemic plant that flowers in June-July, bears fruit in July-August, and grows on slopes in the upper mountain zone. We studied the aerial part of S. holosericea collected during flowering in Surkhandar′ya Region, Republic of Uzbekistan. Ground and air-dried raw material (300 g) was extracted exhaustively (5×) by EtOH (70%) at room temperature. The combined extracts were distilled in vacuo. The condensed residue was diluted with H2O and worked up successively by hydrocarbons, CHCl3, EtOAc, and n-BuOH.

The EtOAc (12 g) and n-BuOH (14 g) fractions were chromatographed over a column of silica gel using gradients of hydrocarbons:CHCl3 (1) and CHCl3:MeOH (2). The chrom