The homogeneous polysaccharide S b RP-1″ with MW 110 kDa was isolated during an investigation of water-soluble polysaccharides from Scutellaria baicalensis roots. Its aqueous solution gave a positive reaction with iodine and exhibited high specific rotation ([α]D +188.0°). Chemical, chromatographic, and spectral methods established that S b RP-1″ was a slightly branched glucan containing in the main chain α-(1 → 4)-glucopyranose units, 8.3% of which were branched at the C-6 atom with single α-glucopyranose units. Glucan S b RP-1″ was shown to exhibit immunostimulating activity using an azathioprine model of immunosuppression.
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The work was supported financially by the Lavrent’ev Award for Young Scientists, SB, RAS.
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Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 176–179, March–April, 2011.
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Olennikov, D.N., Stolbikova, A.V., Rokhin, A.V. et al. Carbohydrates from Lamiaceae. VIII. α-Glucan from Scutellaria baicalensis roots. Chem Nat Compd 47, 190–193 (2011). https://doi.org/10.1007/s10600-011-9878-4
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DOI: https://doi.org/10.1007/s10600-011-9878-4