Reactions of 5-(het)aryl-1-ethyl-2(1H )-pyrazinones with terminal arylacetylenes promoted by microwave radiation

  • E. V. Verbitskiy
  • E. M. Cheprakova
  • P. A. Slepuhin
  • M. G. Pervova
  • M. A. Samorukova
  • O. N. Zabelina
  • G. L. Rusinov
  • V. N. Charushin
Article

DOI: 10.1007/s10593-011-0824-y

Cite this article as:
Verbitskiy, E.V., Cheprakova, E.M., Slepuhin, P.A. et al. Chem Heterocycl Comp (2011) 47: 710. doi:10.1007/s10593-011-0824-y

The reaction of 5-(het)aryl-1-ethyl-2(1H)-pyrazinones with terminal arylacetylenes, leading to a mixture of two isomeric 4-aryl- and 5-aryl-substituted 2(1H)-pyridones has been investigated. The regioselectivity of this reaction has been shown on the basis of reaction mixtures study by chromato-mass spectrometry. A crystallographic investigation of the synthesized 2(1H)-pyridones and also a forecast of their potential biological activity have been carried out.

Keywords

σH-adducts arylacetylenes 1,2-dihydropyrazines ionic liquid 2(1H)-pyrazinones 2(1H)-pyridones microwave radiation 

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • E. V. Verbitskiy
    • 1
  • E. M. Cheprakova
    • 1
  • P. A. Slepuhin
    • 1
  • M. G. Pervova
    • 1
  • M. A. Samorukova
    • 1
  • O. N. Zabelina
    • 1
  • G. L. Rusinov
    • 1
  • V. N. Charushin
    • 1
  1. 1.I. Ya. Postovskii Institute of Organic Synthesis, Ural Branch of the Russian Academy of SciencesYekaterinburgRussia

Personalised recommendations