Reactions of 5-(het)aryl-1-ethyl-2(1H )-pyrazinones with terminal arylacetylenes promoted by microwave radiation
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- Verbitskiy, E.V., Cheprakova, E.M., Slepuhin, P.A. et al. Chem Heterocycl Comp (2011) 47: 710. doi:10.1007/s10593-011-0824-y
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The reaction of 5-(het)aryl-1-ethyl-2(1H)-pyrazinones with terminal arylacetylenes, leading to a mixture of two isomeric 4-aryl- and 5-aryl-substituted 2(1H)-pyridones has been investigated. The regioselectivity of this reaction has been shown on the basis of reaction mixtures study by chromato-mass spectrometry. A crystallographic investigation of the synthesized 2(1H)-pyridones and also a forecast of their potential biological activity have been carried out.