4-Hydroxy-2-quinolones. 194*. 1-Hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid alkylamides. Synthesis, structure, and biological properties

  • I. V. Ukrainets
  • N. Yu. Golik
  • K. V. Andreeva
  • O. V. Gorokhova
Article

DOI: 10.1007/s10593-011-0692-5

Cite this article as:
Ukrainets, I.V., Golik, N.Y., Andreeva, K.V. et al. Chem Heterocycl Comp (2011) 46: 1459. doi:10.1007/s10593-011-0692-5

Modified methods are proposed for the preparation of the ethyl ester and alkylamides of 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid. A comparative analysis has been carried out of the steric structure and diuretic activity of the synthesized compounds and the previously studied, and closely structurally related, 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo-[3,2,1-ij]quinoline-2-carboxamides.

Keywords

4-hydroxy-2-oxoquinoline-3-carboxylic acid alkylamidesamidationdiuretic activityX-ray structural analysis

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • I. V. Ukrainets
    • 1
  • N. Yu. Golik
    • 1
  • K. V. Andreeva
    • 1
  • O. V. Gorokhova
    • 1
  1. 1.National University of PharmacyKharkivUkraine