, Volume 45, Issue 7, pp 796-801
Date: 27 Oct 2009

Preparation of N-phenyl-substituted quinolinium derivatives labeled with tritium by chemonuclear synthesis

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A chemonuclear method of synthesis is proposed for obtaining difficultly available phenyl-substituted derivatives of quinoline labeled with tritium. The ion-molecule reaction of free phenyl cations, generated on β-decay of tritium, with the nucleophilic centers of heterocyclic compounds is the basis of the synthesis. The onium derivatives synthesized possess significant inhibitory antimicrobial activity and are promising for a detailed study of the reaction mechanisms and metabolic processes using radioactive indicators.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1008-1014, July, 2009.