Preparation of N-phenyl-substituted quinolinium derivatives labeled with tritium by chemonuclear synthesis
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- Shchepina, N.E., Avrorin, V.V., Badun, G.A. et al. Chem Heterocycl Comp (2009) 45: 796. doi:10.1007/s10593-009-0359-7
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A chemonuclear method of synthesis is proposed for obtaining difficultly available phenyl-substituted derivatives of quinoline labeled with tritium. The ion-molecule reaction of free phenyl cations, generated on β-decay of tritium, with the nucleophilic centers of heterocyclic compounds is the basis of the synthesis. The onium derivatives synthesized possess significant inhibitory antimicrobial activity and are promising for a detailed study of the reaction mechanisms and metabolic processes using radioactive indicators.