Clinical & Experimental Metastasis

, Volume 29, Issue 2, pp 165–178

Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling

Authors

  • Jiahua Jiang
    • Cancer Research Laboratory, Methodist Research InstituteIndiana University Health
  • Veronika Slivova
    • Cancer Research Laboratory, Methodist Research InstituteIndiana University Health
  • Andrej Jedinak
    • Cancer Research Laboratory, Methodist Research InstituteIndiana University Health
    • Cancer Research Laboratory, Methodist Research InstituteIndiana University Health
    • Department of MedicineIndiana University
    • Indiana University Simon Cancer Center, School of MedicineIndiana University
Research Paper

DOI: 10.1007/s10585-011-9439-z

Cite this article as:
Jiang, J., Slivova, V., Jedinak, A. et al. Clin Exp Metastasis (2012) 29: 165. doi:10.1007/s10585-011-9439-z

Abstract

Although previous studies demonstrated anticancer activities of gossypol through the induction of apoptosis, the molecular mechanism(s) responsible for the inhibitory effects of gossypol on the metastatic behavior of cancer cells remain to be elucidated. Here, we show that gossypol inhibits growth of human prostate cancer cells through the modulation of cell cycle regulatory proteins. We also demonstrate that gossypol inhibits invasive behaviors (adhesion, migration, and invasion) and angiogenesis. These effects are mediated by the suppression of AP-1 and NF-κB activity, resulting in the inhibition of secretion of urokinase plasminogen activator and vascular endothelial growth factor, and the down-regulation of expression of chemokine receptor 4 in PC3 cells. In summary, our data suggest that gossypol could have potential therapeutic effect for the treatment of invasive prostate cancer.

Keywords

GossypolCell cycleInvasionMigrationMetastasisAngiogenesisNF-κBAP-1

Copyright information

© Springer Science+Business Media B.V. 2011