Clinical & Experimental Metastasis

, Volume 29, Issue 2, pp 165–178

Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling

  • Jiahua Jiang
  • Veronika Slivova
  • Andrej Jedinak
  • Daniel Sliva
Research Paper

DOI: 10.1007/s10585-011-9439-z

Cite this article as:
Jiang, J., Slivova, V., Jedinak, A. et al. Clin Exp Metastasis (2012) 29: 165. doi:10.1007/s10585-011-9439-z

Abstract

Although previous studies demonstrated anticancer activities of gossypol through the induction of apoptosis, the molecular mechanism(s) responsible for the inhibitory effects of gossypol on the metastatic behavior of cancer cells remain to be elucidated. Here, we show that gossypol inhibits growth of human prostate cancer cells through the modulation of cell cycle regulatory proteins. We also demonstrate that gossypol inhibits invasive behaviors (adhesion, migration, and invasion) and angiogenesis. These effects are mediated by the suppression of AP-1 and NF-κB activity, resulting in the inhibition of secretion of urokinase plasminogen activator and vascular endothelial growth factor, and the down-regulation of expression of chemokine receptor 4 in PC3 cells. In summary, our data suggest that gossypol could have potential therapeutic effect for the treatment of invasive prostate cancer.

Keywords

GossypolCell cycleInvasionMigrationMetastasisAngiogenesisNF-κBAP-1

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Jiahua Jiang
    • 1
  • Veronika Slivova
    • 1
  • Andrej Jedinak
    • 1
  • Daniel Sliva
    • 1
    • 2
    • 3
  1. 1.Cancer Research Laboratory, Methodist Research InstituteIndiana University HealthIndianapolisUSA
  2. 2.Department of MedicineIndiana UniversityIndianapolisUSA
  3. 3.Indiana University Simon Cancer Center, School of MedicineIndiana UniversityIndianapolisUSA