Clinical & Experimental Metastasis

, Volume 28, Issue 5, pp 493-503

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature

  • J. PosthumaDeBoerAffiliated withDepartment of Orthopaedic Surgery, VU University Medical Center
  • , M. A. WitloxAffiliated withDepartment of Orthopaedic Surgery, Westfries Gasthuis
  • , G. J. L. KaspersAffiliated withPaediatric Oncology/Haematology, VU University Medical Center
  • , B. J. van RoyenAffiliated withDepartment of Orthopaedic Surgery, VU University Medical CenterVU University Medical Center Email author 


Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment strategies target the primary tumour rather than metastases and have a limited efficacy in the treatment of metastatic disease. Metastatic cells have specific features that render them less sensitive to therapy and targeting these features might enhance the efficacy of current treatment. A detailed study of the biological characteristics and behaviour of metastatic OS cells may provide a rational basis for innovative treatment strategies. The aim of this review is to give an overview of the biological changes in metastatic OS cells and the preclinical and clinical efforts targeting the different steps in OS metastases and how these contribute to designing a metastasis directed treatment for OS.


Drug resistance Metastasis Osteosarcoma Therapy