Clinical & Experimental Metastasis

, Volume 26, Issue 7, pp 839–848

Prognostic factors and recurrence of hepatitis B-related hepatocellular carcinoma after argon-helium cryoablation: a prospective study

Authors

  • Chunping Wang
    • Center of Therapeutic Research for Hepatocellular Carcinoma
  • Yinying Lu
    • Center of Therapeutic Research for Hepatocellular Carcinoma
  • Yan Chen
    • Center of Therapeutic Research for Hepatocellular Carcinoma
  • Yongyi Feng
    • Center of Therapeutic Research for Hepatocellular Carcinoma
  • Linjing An
    • Center of Therapeutic Research for Hepatocellular Carcinoma
  • Xinzhen Wang
    • Center of Therapeutic Research for Hepatocellular Carcinoma
  • Shuhui Su
    • Center of Therapeutic Research for Hepatocellular Carcinoma
  • Wenlin Bai
    • Center of Therapeutic Research for Hepatocellular Carcinoma
  • Lin Zhou
    • Center of Therapeutic Research for Hepatocellular Carcinoma
    • Center of Therapeutic Research for Hepatocellular Carcinoma
  • Dongping Xu
    • Infectious Disease Institute of PLA
Research paper

DOI: 10.1007/s10585-009-9283-6

Cite this article as:
Wang, C., Lu, Y., Chen, Y. et al. Clin Exp Metastasis (2009) 26: 839. doi:10.1007/s10585-009-9283-6

Abstract

To determine the long-term prognosis of hepatocellular carcinoma (HCC) after argon-helium cryoablation and identify the risk factors that predict metastasis and recurrence. A total of 156 patients with hepatitis B-related HCC less than 5 cm in diameter who underwent curative cryoablation were followed up prospectively for tumor metastasis and recurrence. Immunohistochemistry was used to analyze the expression of vascular endothelial growth factor (VEGF). HBV basal core promoter (BCP) and precore mutations were detected by DNA sequence analysis. Post-treatment prognostic factors influencing survival, tumor metastasis and recurrence were assessed by univariate and multivariate analyses. The variables included the expression of VEGF in HCC tissues, clinical and pathologic characteristics of patients, and HBV features (HBV DNA level, HBV genotype, BCP mutation). The median follow-up period of the 156 patients was 37 months (range 8–48 months). The 1-, 2-, and 3-year overall survival rates were 92, 82 and 64%, respectively. The 1-, 2-, and 3-year recurrence-free survival rates were 72, 56 and 43%, respectively. Eighty-five patients (54.5%) had tumor recurrence or metastasis. The multivariate analysis showed that Child-Pugh class and the expression of VEGF in HCC tissues could be used as independent prognostic factors for overall survival. Meanwhile, the expression of VEGF in HCC tissues and HBV BCP mutations were found to be independent prognostic factors for recurrence-free survival. Strong expression of VEGF in HCC tissues and HBV BCP mutations are important risk predictors for recurrence or metastasis of HCC smaller than 5 cm in diameter.

Keywords

Hepatocellular carcinomaCryoablationPrognostic factorRecurrenceVascular endothelial growth factorHBV basal core promoter

Abbreviations

CT

Computed tomography

MRI

Magnetic resonance imaging

PCR

Polymerase chain reaction

Copyright information

© Springer 2009