Review

Clinical & Experimental Metastasis

, Volume 26, Issue 6, pp 559-567

First online:

Multi-faceted role of HSP40 in cancer

  • Aparna MitraAffiliated withDepartment of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama
  • , Lalita A. ShevdeAffiliated withDepartment of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama
  • , Rajeev S. SamantAffiliated withDepartment of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama Email author 

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Abstract

HSP40 (DNAJ) is an understudied family of co-chaperones. The human genome codes for over 41 members of HSP40 family that reside at distinct intracellular locations. Despite their large numbers, little is known about their physiologic roles. Recent research has revealed involvement of some of the DNAJ family members in various types of cancers. In this article we summarize the information about the involvement of human DNAJ family members in various aspects of cancer biology. Furthermore we discuss the potential role of the J domain of DNAJ proteins in cancer biology.

Keywords

HSP40 DnaJ Cancer