Clinical & Experimental Metastasis

, Volume 25, Issue 8, pp 871–875

Time to metastatic relapse and breast cancer cells dissemination in bone marrow at metastatic relapse

  • François-Clément Bidard
  • Anne Vincent-Salomon
  • Brigitte Sigal-Zafrani
  • Manuel Rodrigues
  • Véronique Diéras
  • Laurent Mignot
  • Xavier Sastre-Garau
  • Marie-France Poupon
  • Jean-Yves Pierga
Research Paper

DOI: 10.1007/s10585-008-9203-1

Cite this article as:
Bidard, FC., Vincent-Salomon, A., Sigal-Zafrani, B. et al. Clin Exp Metastasis (2008) 25: 871. doi:10.1007/s10585-008-9203-1

Abstract

Breast cancer dissemination can be monitored in patients by detecting circulating and/or disseminated tumor cells. However, bone marrow disseminated tumor cells (BM DTC) may undergo a dormancy during several years before growing (or not) into clinically detectable metastases. We therefore hypothesized that breast cancers which have formed BM DTC in the course of their metastatic growth might exhibit a longer interval before metastatic relapse. We examined the association of DTC detection (cytokeratin 8, 18 or 19 positive epithelial cells with cancerous morphological features), at metastatic relapse, with the metastasis-free interval in breast cancer patients. In the 110 metastatic patients studied, 42% (n = 64/110) were classified as BM DTC-negative. These patients had a significantly shorter metastasis-free interval than BM DTC-positive patients (P = 0.02). In multivariate logistic regression analysis, the metastasis-free interval was an independent predictor of DTC detection (P = 0.02), together with bone metastasis (P = 0.0003) and low tumor grade (grade I or II, P = 0.05). We finally suggest that a faster metastatic process might skip in some patients the BM DTC-associated dormancy step. Dissemination of DTC in other host organ and/or epithelial–mesenchymal transition from cytokeratin-positive to cytokeratin-negative DTC may explain this observation.

Keywords

Disseminated tumor cells Bone marrow Micrometastasis Metastasis Breast cancer 

Abbreviations

BM

Bone marrow

DTC

Disseminated tumor cells

MNC

Mononucleated cells

ER

Estrogen receptor

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • François-Clément Bidard
    • 1
  • Anne Vincent-Salomon
    • 2
  • Brigitte Sigal-Zafrani
    • 2
  • Manuel Rodrigues
    • 1
  • Véronique Diéras
    • 1
  • Laurent Mignot
    • 1
  • Xavier Sastre-Garau
    • 2
  • Marie-France Poupon
    • 3
  • Jean-Yves Pierga
    • 1
    • 4
  1. 1.Department of Medical OncologyInstitut CurieParisFrance
  2. 2.Department of PathologyInstitut CurieParisFrance
  3. 3.Department of Translational ResearchInstitut CurieParisFrance
  4. 4.University Paris DescartesParisFrance

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