Clinical & Experimental Metastasis

, Volume 22, Issue 1, pp 85–93

Frequent loss of membranous E-cadherin in gastric cancers: A cross-talk with Wnt in determining the fate of β-catenin

Authors

  • Xiao-Xin Cheng
    • Cancer Institute and The Liaoning Provincial Key Laboratory of Cancer Genomics, College of Basic Medical SciencesDalian Medical University
  • Zi-Chuang Wang
    • Cancer Institute and The Liaoning Provincial Key Laboratory of Cancer Genomics, College of Basic Medical SciencesDalian Medical University
  • Xiao-Yan Chen
    • Cancer Institute and The Liaoning Provincial Key Laboratory of Cancer Genomics, College of Basic Medical SciencesDalian Medical University
  • Yuan Sun
    • Cancer Institute and The Liaoning Provincial Key Laboratory of Cancer Genomics, College of Basic Medical SciencesDalian Medical University
  • Qing-You Kong
    • Cancer Institute and The Liaoning Provincial Key Laboratory of Cancer Genomics, College of Basic Medical SciencesDalian Medical University
  • Jia Liu
    • Cancer Institute and The Liaoning Provincial Key Laboratory of Cancer Genomics, College of Basic Medical SciencesDalian Medical University
  • Xue Gao
    • Cancer Institute and The Liaoning Provincial Key Laboratory of Cancer Genomics, College of Basic Medical SciencesDalian Medical University
    • Division of Pathology, First Affiliated HospitalDalian Medical University
  • Hong-Wei Guan
    • Division of Pathology, First Affiliated HospitalDalian Medical University
    • Cancer Institute and The Liaoning Provincial Key Laboratory of Cancer Genomics, College of Basic Medical SciencesDalian Medical University
Article

DOI: 10.1007/s10585-005-4578-8

Cite this article as:
Cheng, X., Wang, Z., Chen, X. et al. Clin Exp Metastasis (2005) 22: 85. doi:10.1007/s10585-005-4578-8

Abstract

The potential correlation of E-cadherin reduction and Wnt2 up-regulation in determining the intracellular distribution of β-catenin in gastric cancers was investigated by the methods of frozen tissue array-based immunohistochemistry, Western blot and RT-PCR analysis. It was revealed that membranous E-cadherin was reduced frequently in the two major subtypes of gastric cancer (intestinal gastric cancer, i-GC and diffuse gastric cancer, d-GC) and closely correlated with the risk of lymphoid node metastasis (P < 0.05). The reduction of membranous E-cadherin was paralleled with cytosolic and nuclear accumulation of β-catenin and the increased Wnt2 expression. These results indicate that the reduced E-cadherin is a common genetic phenotype of GCs and plays beneficial roles in tumor metastasis. Altered β-catenin distribution may result from the imbalance of E-cadherin production and Wnt expression, which confers on gastric cancer cells more aggressive behaviors.

Keywords

β-cateninE-cadheringastric cancermetastasisWnt2
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Copyright information

© Springer 2005