Czechoslovak Journal of Physics

, Volume 49, Supplement 1, pp 817–822

Production of AC-225 and application of the BI-213 daughter in cancer therapy

  • L. Koch
  • C. Apostolidis
  • W. Janssens
  • R. Molinet
  • J. Van Geel
Production and Application of Radionuclides

DOI: 10.1007/s10582-999-1001-8

Cite this article as:
Koch, L., Apostolidis, C., Janssens, W. et al. Czech J Phys (1999) 49(Suppl 1): 817. doi:10.1007/s10582-999-1001-8

Abstract

There are several ongoing medical trials to use Bi-213 conjugated to monoclonal antibodies to kill tumour-cells of various cancer types. The institute is supplying Ac-225 generators for the test and is itself engaged in in-vitro cytotoxicity tests. Nuclear reactions leading to Ac-225 are discussed. The present supply of Ac-225 stems from Th-229 decay obtained from aged U-233. From the possible alternative the reactions Ra-226 (p, 2n) Ac-225 is presently favoured. The fabrication of a Ac-225 for Bi-213 generator will be described.

Copyright information

© Institute of Physics, Acad. Sci. CR 1999

Authors and Affiliations

  • L. Koch
    • 1
  • C. Apostolidis
    • 1
  • W. Janssens
    • 1
  • R. Molinet
    • 1
  • J. Van Geel
    • 1
  1. 1.Institute for Transuranium ElementsEuropean Commission-JRCKarlsruheGermany

Personalised recommendations