Child Psychiatry and Human Development

, Volume 36, Issue 2, pp 155–165

The Relationship Between Restrictive and Repetitive Behaviors in Individuals with Autism and Obsessive Compulsive Symptoms in Parents

  • RK Abramson
  • SA Ravan
  • HH Wright
  • K Wieduwilt
  • CM Wolpert
  • SA Donnelly
  • MA Pericak-Vance
  • ML Cuccaro
Article

DOI: 10.1007/s10578-005-2973-7

Cite this article as:
Abramson, R., Ravan, S., Wright, H. et al. Child Psychiatry Hum Dev (2005) 36: 155. doi:10.1007/s10578-005-2973-7

Abstract

This study investigated the relationship between repetitive behaviors in individuals with autism and obsessive-compulsive behaviors in parents. We hypothesized that repetitive behaviors in probands with autism would be associated with increased obsessive-compulsive behaviors in parents in sporadic families (1 known case of autism per family and no known history of autism). Parents with clinically significant Y-BOCS scores were more likely to have a family history of obsessive-compulsive disorder. The empirically derived Autism Diagnostic Interview-R (ADI-R) factor, Insistence on Sameness, was positively correlated with obsessive-compulsive behaviors in parents. Further, when probands were grouped on the basis of parental Y-BOCS scores (clinically significant versus non-clinically significant), probands whose parents had clinically significant Y-BOCS scores had higher ADI-R Insistence on Sameness factor scores. The findings of the current study of sporadic families extend previous work that has shown an association between restrictive/repetitive behaviors in probands with autism and obsessive-compulsive features in parents.

Key words

autismrepetitive behaviorsinsistence on samenessobsessive-com-pulsive featuresphenotype

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • RK Abramson
    • 1
  • SA Ravan
    • 1
  • HH Wright
    • 1
  • K Wieduwilt
    • 1
  • CM Wolpert
    • 2
  • SA Donnelly
    • 2
  • MA Pericak-Vance
    • 2
  • ML Cuccaro
    • 2
  1. 1.W.S. Hall Psychiatric InstituteUniversity of South CarolinaUSA
  2. 2.Center for Human GeneticsDuke University Medical CenterUSA
  3. 3.Center for Human GeneticsDuke University Medical CenterDurhamUSA