, Volume 19, Issue 3, pp 307-319
Date: 02 Apr 2011

How to be a mitotic chromosome

Abstract

Proper mitotic chromosome structure is essential for faithful chromosome segregation. Mounting evidence suggests that mitotic chromosome assembly is a progressive, dynamic process that requires topoisomerase II, condensins and cohesin and the activity of several signalling molecules. Current results suggest how these different activities might interact to achieve the familiar form of the mitotic chromosome.

Responsible Editors: James Wakefield and Herbert Macgregor.