Chromosome Research

, Volume 17, Issue 2, pp 131–144

Condensin: Architect of mitotic chromosomes

Article

DOI: 10.1007/s10577-008-9009-7

Cite this article as:
Hudson, D.F., Marshall, K.M. & Earnshaw, W.C. Chromosome Res (2009) 17: 131. doi:10.1007/s10577-008-9009-7

Abstract

Condensin is a highly conserved pentameric complex consisting of two structural maintenance of chromosome (SMC) ATPase subunits and three auxiliary components. While initially regarded as a key driver of mitotic chromosome condensation, condensin is increasingly viewed as having a more subtle influence on chromosome architecture. The two condensin complexes are required to direct the correct folding and organization of chromosomes prior to anaphase and for keeping the chromosomes compact as they separate to the poles. This ancient complex is essential in mitosis and meiosis and has additional roles in gene regulation and DNA repair. The wide variety of biochemical and genetic tools available are gradually unravelling the numerous roles condensin plays during the cell cycle and shedding light on its mechanism of action.

Keywords

condensinSMC2SMC4mitosischromosome

Abbreviations

CAP

chromosome-associated protein

Cdc2

cell division cycle (kinase) 2

CDK

cyclin-dependent kinase

CK2

casein kinase 2

HEAT

Huntingtin, elongation factor 3, the A subunit of protein phosphatase 2A, TOR lipid kinase

NEBD

nuclear envelope breakdown

RCA

regulator of chromosome architecture

SMC

structural maintenance of chromosome

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  1. 1.Murdoch Children’s Research InstituteRoyal Children’s HospitalMelbourneAustralia
  2. 2.Department of PaediatricsUniversity of Melbourne, Royal Children’s HospitalMelbourneAustralia
  3. 3.Department of SurgeryUniversity of Melbourne, Austin HealthHeidelbergAustralia
  4. 4.Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular BiologyUniversity of EdinburghEdinburghUK