Cellular and Molecular Neurobiology

, Volume 37, Issue 3, pp 377–388

Autophagy and Alzheimer’s Disease

Review Paper

DOI: 10.1007/s10571-016-0386-8

Cite this article as:
Li, Q., Liu, Y. & Sun, M. Cell Mol Neurobiol (2017) 37: 377. doi:10.1007/s10571-016-0386-8

Abstract

Autophagy is an essential degradation pathway in clearing abnormal protein aggregates in mammalian cells and is responsible for protein homeostasis and neuronal health. Several studies have shown that autophagy deficits occurred in early stage of Alzheimer’s disease (AD). Autophagy plays an important role in generation and metabolism of β-amyloid (Aβ), assembling of tau and thus its malfunction may lead to the progress of AD. By considering the above evidences, autophagy may be a new target in developing drugs for AD. So far, a number of mammalian target of rapamycin (mTOR)-dependent and independent autophagy modulators have been identified to have positive effects in AD treatment. In this review, we summarized the latest progress supporting the role for autophagy deficits in AD and the potential therapeutic effects of autophagy modulators in AD.

Keywords

Autophagyβ-AmyloidTauAlzheimer’s disease

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Neuroscience Research InstitutePeking UniversityBeijingChina
  2. 2.Department of Neurology, Dalian Municipal Central HospitalAffiliated Hospital of Dalian Medical UniversityDalianChina
  3. 3.Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical SchoolRutgers UniversityPiscatawayUSA