Cellular and Molecular Neurobiology

, Volume 30, Issue 4, pp 631–640

The Genome-Wide Expression Profile of Electroacupuncture in DNP-KLH Immunized Mice

  • Sung-Hwa Sohn
  • Sun Kwang Kim
  • Eunjung Ko
  • Youngseop Lee
  • Hwan-Suck Chung
  • Hyojung Lee
  • Hyunseong Kim
  • Deok-Sang Hwang
  • Sangsoo Nam
  • Hyunsu Bae
Original Research

DOI: 10.1007/s10571-009-9487-y

Cite this article as:
Sohn, SH., Kim, S.K., Ko, E. et al. Cell Mol Neurobiol (2010) 30: 631. doi:10.1007/s10571-009-9487-y

Abstract

Previously, we demonstrated that electoracupuncture (EA) suppressed allergic reactions in DNP-KLH immunized mice. In this study, the mechanisms by which EA induces immunomodulation in the immunized mice were evaluated by genome-wide microarray analysis. The anti-allergic effects of EA in DNP-KLH immunized mice were confirmed by analyzing antigen specific IgE using ELISA. Microarray analysis, followed by real time RT–PCR validation, revealed that Th1 and Th17 cytokine-, opioid peptide-, and anti-apoptosis-related genes were up-regulated upon treatment with EA. In addition, significant decreases in Th2 cytokine-, MAPK signaling pathway-, and apoptosis-related genes were observed following EA treatment.

Keywords

Electroacupuncture Gene expression profile IgE Microarray 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Sung-Hwa Sohn
    • 4
  • Sun Kwang Kim
    • 1
  • Eunjung Ko
    • 1
  • Youngseop Lee
    • 1
    • 5
  • Hwan-Suck Chung
    • 1
  • Hyojung Lee
    • 1
  • Hyunseong Kim
    • 1
  • Deok-Sang Hwang
    • 2
  • Sangsoo Nam
    • 3
  • Hyunsu Bae
    • 1
  1. 1.Department of Physiology, College of Oriental MedicineKyung Hee UniversitySeoulRepublic of Korea
  2. 2.Department of Oriental GynecologyCollege of Oriental Medicine, Kyung Hee UniversitySeoulRepublic of Korea
  3. 3.Department of Acupuncture & MoxibustionCollege of Oriental Medicine, Kyung Hee UniversitySeoulRepublic of Korea
  4. 4.Brain Korea 21 Project for Medical ScienceYonsei UniversitySeoulRepublic of Korea
  5. 5.Department of Medical ResearchKorea Institute of Oriental MedicineDaejeonRepublic of Korea

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