Beyond the Rat Models of Human Neurodegenerative Disorders

Original Paper

DOI: 10.1007/s10571-009-9367-5

Cite this article as:
Bugos, O., Bhide, M. & Zilka, N. Cell Mol Neurobiol (2009) 29: 859. doi:10.1007/s10571-009-9367-5

Abstract

The rat is a model of choice in biomedical research for over a century. Currently, the rat presents the best “functionally” characterized mammalian model system. Despite this fact, the transgenic rats have lagged behind the transgenic mice as an experimental model of human neurodegenerative disorders. The number of transgenic rat models recapitulating key pathological hallmarks of Alzheimer’s disease, Huntington’s disease, amyotrophic lateral sclerosis, or human tauopathies is still limited. The reason is that the transgenic rats remain more difficult to produce than transgenic mice. The gene targeting technology is not yet established in rats due to the lack of truly totipotent embryonic stem cells and cloning technology. This extremely powerful technique has given the mouse a clear advantage over the rat in generation of new transgenic models. Despite these limitations, transgenic rats have greatly expanded the range of potential experimental approaches. The large size of rats permits intrathecal administration of drugs, stem cell transplantation, serial sampling of the cerebrospinal fluid, microsurgical techniques, in vivo nerve recordings, and neuroimaging procedures. Moreover, the rat is routinely employed to demonstrate therapeutic efficacy and to assess toxicity of novel therapeutic compounds in drug development. Here we suggest that the rat constitutes a slightly underestimated but perspective animal model well-suited for understanding the mechanisms and pathways underlying the human neurodegenerative disorders.

Keywords

Rat modelsNeurodegenerative disordersTransgenesisAlzheimer’s diseaseTauopathies

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Institute of NeuroimmunologySlovak Academy of Sciences, AD CentreBratislavaSlovak Republic
  2. 2.Axon-Neuroscience GmbHViennaAustria
  3. 3.Laboratory of Biomedical Microbiology and ImmunologyUniversity of Veterinary MedicineKosiceSlovak Republic