Biochemical and Clinical Improvement of Cytotoxic State by Amantadine Sulphate
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1. The main idea of the open clinical trial was to compare the income and outcome clinical picture and the evolution of the biochemical markers in the defined intervals in closed head injury group patients.
2. In the group of 32 patients, mean age 40.78±15.36 years suffering from closed traumatic brain injury the following markers were measured: glycaemia, malondialdehyde (MDA) as marker of lipid peroxidation, beta-caroten, total SH groups as marker of protein oxidation in the following intervals: between the 1st and the 3rd, between the 3rd and the 7th, between the 1st and the 7th day respectively.
3. Glycaemia significantly decreased since the 1st day till the 3rd day (p < 0.05) and since the 1st day till the 7th day (p < 0.05) but it was not significantly changed since the 3rd day till the 7th day (p > 0.05).
4. MDA 1st × MDA 3rd p > 0.05 insignificant change, MDA 1st × MDA 7th p < 0.001—high significant decrease, MDA 3rd × MDA 7th—p < 0.0001—very high significant decrease.
5. Beta-caroten the 1st × beta-caroten the 3rd day was insignificantly changed—p > 0.05, the 3rd × the 7th day beta-caroten increased significantly—p < 0.0002, the 1st day × 7th day beta-caroten significantly increased—p < 0.0001.
6. We examined the SH groups only in nine patients, due to technical problems and SH groups decrease on the 3rd day (p < 0.005).
7. In 18 amantadine sulphate subgroups (randomly selected), there was 5.5% lethality and mean outcome GCS (outGCS) 9.83±3.8, while lethality of the control subgroup (n=14) was 42.9%, mean outGCS 6.28±3.5.
- Biochemical and Clinical Improvement of Cytotoxic State by Amantadine Sulphate
Cellular and Molecular Neurobiology
Volume 26, Issue 7-8 , pp 1473-1480
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- Kluwer Academic Publishers-Plenum Publishers
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- brain injury
- antioxidative state
- free oxygen radicals
- income and outcome glasgow coma scale
- Industry Sectors
- Author Affiliations
- 1. Clinic of Anaesthesiology and Intensive Medicine, Jessenius Faculty of Medicine, Faculty Hospital, Martin, Slovak Republic
- 4. Institute of Clinical Biochemistry, Jessenius Faculty of Medicine, Faculty Hospital, Martin, Slovakia
- 2. Clinic of Neurology, Jessenius Faculty of Medicine, Faculty Hospital, Martin, Slovakia
- 3. Institute of Medical Biochemistry, Jessenius Faculty of Medicine, Faculty Hospital, Martin, Slovakia